One-pot multicomponent synthesis of novel pyridine derivatives for antidiabetic and antiproliferative activities

Due to the close relationship of diabetes with hypertension reported in various research, a set of pyridine derivatives with US FDA-approved drug cores was designed and integrated by artificial intelligence. Novel pyridines were designed and synthesized. Compounds – were evaluated for their structure and were screened for their antidiabetic (α-amylase) activity and anticancer (HepG2) activity by methyl thiazolyl tetrazolium assay. Comparative 3D quantitative structure–activity relationship analysis and pharmacophore generation were carried out. The study revealed and as good alternatives to acarbose as antidiabetic agents, and as a more viable, better alternative to doxorubicin in the methyl thiazolyl tetrazolium assay. This combination of studies identifies new and more active analogs of existing FDA-approved drugs for the treatment of diabetes.