Adenovirus-Associated Thrombocytopenia, Thrombosis, and VITT-like Antibodies

VITT is caused by antibodies to PF4 that recognize the heparin-binding site. Thrombocytopenia and thrombosis associated with VITT-like antibody specificity developed in a child and an adult after adenovirus infection.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-08, Vol.389 (6), p.574-577
Hauptverfasser:	Warkentin, Theodore E., Baskin-Miller, Jacquelyn, Raybould, Alison L., Sheppard, Jo-Ann I., Daka, Mercy, Nazy, Ishac, Moll, Stephan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae Adenoviridae Infections - complications Adenovirus Adenovirus Vaccines - adverse effects Adenoviruses Allergy Amino acids Antibodies Anticoagulants Anticoagulation Apheresis Autoimmune Disease Cardiology Coagulation COVID-19 Critical Care Enzymes Glycoproteins Heart attacks Hematology Heparin Humans Immunoassay Immunology Infections Infectious Disease Mutation Neurology Neurosurgery Oncology Patients Polymerase chain reaction Pulmonary Purpura, Thrombocytopenic, Idiopathic - chemically induced Purpura, Thrombocytopenic, Idiopathic - etiology Severe acute respiratory syndrome coronavirus 2 Sinuses Stroke Thrombocytopenia Thrombocytopenia - etiology Thromboembolism Thrombosis Thrombosis - etiology Vaccines Veins & arteries Viral Infections
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Beschreibung
Zusammenfassung:	VITT is caused by antibodies to PF4 that recognize the heparin-binding site. Thrombocytopenia and thrombosis associated with VITT-like antibody specificity developed in a child and an adult after adenovirus infection.
ISSN:	0028-4793 1533-4406 1533-4406
DOI:	10.1056/NEJMc2307721