Spatial transcriptomic profiling reveals the pathophysiology of early-stage hidradenitis suppurativa

We investigated the role of the epithelium of nodules in Hurley stage I hidradenitis suppurativa (HS) by using spatial transcriptomics to analyse the profiles of epithelial cells and dermal-infiltrating immune cells. Compared with epidermal cysts, genes related to bacterial response, inflammatory me...

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Veröffentlicht in:British journal of dermatology (1951) 2023-10, Vol.189 (5), p.643-645
Hauptverfasser: Suh-Yun Joh, Christine, Jeong, Soyoung, Lee, Cheol, Lee, Hee Jung, Lee, Jung Ho, Choi, Hyun Seung, Cho, Soyun, Kim, Gwangil, Kim, Jaehwan, Krueger, James G, Park, Chung-Gyu, Shin, Jung U, Jin, Seon-Pil, Kim, Hyun Je
Format: Artikel
Sprache:eng
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Zusammenfassung:We investigated the role of the epithelium of nodules in Hurley stage I hidradenitis suppurativa (HS) by using spatial transcriptomics to analyse the profiles of epithelial cells and dermal-infiltrating immune cells. Compared with epidermal cysts, genes related to bacterial response, inflammatory mediators and neutrophil degranulation pathways were upregulated in the epithelial cells of early-stage HS nodules. Our analysis of dermal-infiltrating immune cells surrounding the epithelium of nodules revealed significantly elevated levels of B-cell-related genes. Similarly to the sinus tract formation observed in moderate-to-severe HS, we propose that the production of inflammatory mediators in early-stage HS may involve the activation of keratinocytes and their interaction with dermal-infiltrating immune cells.
ISSN:0007-0963
1365-2133
DOI:10.1093/bjd/ljad274