Spatial transcriptomic profiling reveals the pathophysiology of early-stage hidradenitis suppurativa
We investigated the role of the epithelium of nodules in Hurley stage I hidradenitis suppurativa (HS) by using spatial transcriptomics to analyse the profiles of epithelial cells and dermal-infiltrating immune cells. Compared with epidermal cysts, genes related to bacterial response, inflammatory me...
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Veröffentlicht in: | British journal of dermatology (1951) 2023-10, Vol.189 (5), p.643-645 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We investigated the role of the epithelium of nodules in Hurley stage I hidradenitis suppurativa (HS) by using spatial transcriptomics to analyse the profiles of epithelial cells and dermal-infiltrating immune cells. Compared with epidermal cysts, genes related to bacterial response, inflammatory mediators and neutrophil degranulation pathways were upregulated in the epithelial cells of early-stage HS nodules. Our analysis of dermal-infiltrating immune cells surrounding the epithelium of nodules revealed significantly elevated levels of B-cell-related genes. Similarly to the sinus tract formation observed in moderate-to-severe HS, we propose that the production of inflammatory mediators in early-stage HS may involve the activation of keratinocytes and their interaction with dermal-infiltrating immune cells. |
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ISSN: | 0007-0963 1365-2133 |
DOI: | 10.1093/bjd/ljad274 |