Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)
The milling behaviour of microcrystalline cellulose (MCC) and α -lactose monohydrate ( α LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of α LM is more strongly influenced by the milling...
Gespeichert in:
| Veröffentlicht in: | Chemical engineering science 2005-03, Vol.60 (5), p.1441-1448 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1448 |
|---|---|
| container_issue | 5 |
| container_start_page | 1441 |
| container_title | Chemical engineering science |
| container_volume | 60 |
| creator | Kwan, Chih Chi Mio, Hiroshi Qi Chen, Yong Long Ding, Yu Saito, Fumio Papadopoulos, Dimitris G. Craig Bentham, A. Ghadiri, Mojtaba |
| description | The milling behaviour of microcrystalline cellulose (MCC) and
α
-lactose monohydrate (
α
LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of
α
LM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and
α
LM is described by a first order rate process, and its rate constant,
K
p
, is found to correlate very well with the milling power,
P
n
, determined by the DEM simulation, except for the milling behaviour of
α
LM at 18
Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials. |
| doi_str_mv | 10.1016/j.ces.2004.10.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_28533249</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009250904007687</els_id><sourcerecordid>28533249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-fb5a9e1a51d75c55d1eda71156d5a84afede3eebe397b3461510e9af30b80c873</originalsourceid><addsrcrecordid>eNp9kMtOwzAQRS0EEuXxAey8AcEiZZzESSNWqC0PiYoNbLFce0Jd5VE8Loi_x1GR2LEazejembmHsTMBYwGiuF6PDdI4BchjPwZI99hITMosyXOQ-2wEAFWSSqgO2RHROrZlKWDE3m473XyTI97XPKyQt65pXPfOvQ44zDYr7VttcBuc0Q3f9F8WPfEtDaLBMHMUXGcCnzfYYhf4AsOqt_xyNl9cnbCDWjeEp7_1mL3ezV-mD8nT8_3j9PYpMXkhQlIvpa5QaClsKY2UVqDVpRCysFJPcl2jxQxxiVlVLrNokQKw0nUGywmYGPOYXez2bnz_sUUKqnVksGl0h_2WVDqRWZbmVRSKndD4nshjrTbetdp_KwFqIKnWKpJUA8lhFElGz_nvck2RQe11Zxz9GQsp0gKGJ252OoxJPx16RcZhZ9A6jyYo27t_rvwAd8mI8A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>28533249</pqid></control><display><type>article</type><title>Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)</title><source>Elsevier ScienceDirect Journals</source><creator>Kwan, Chih Chi ; Mio, Hiroshi ; Qi Chen, Yong ; Long Ding, Yu ; Saito, Fumio ; Papadopoulos, Dimitris G. ; Craig Bentham, A. ; Ghadiri, Mojtaba</creator><creatorcontrib>Kwan, Chih Chi ; Mio, Hiroshi ; Qi Chen, Yong ; Long Ding, Yu ; Saito, Fumio ; Papadopoulos, Dimitris G. ; Craig Bentham, A. ; Ghadiri, Mojtaba</creatorcontrib><description>The milling behaviour of microcrystalline cellulose (MCC) and
α
-lactose monohydrate (
α
LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of
α
LM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and
α
LM is described by a first order rate process, and its rate constant,
K
p
, is found to correlate very well with the milling power,
P
n
, determined by the DEM simulation, except for the milling behaviour of
α
LM at 18
Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials.</description><identifier>ISSN: 0009-2509</identifier><identifier>EISSN: 1873-4405</identifier><identifier>DOI: 10.1016/j.ces.2004.10.002</identifier><identifier>CODEN: CESCAC</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>[formula omitted]-lactose monohydrate ; Applied sciences ; Chemical engineering ; DEM simulation ; Exact sciences and technology ; Grinding ; Media mill ; Microcrystalline cellulose ; Solid-solid systems</subject><ispartof>Chemical engineering science, 2005-03, Vol.60 (5), p.1441-1448</ispartof><rights>2004 Elsevier Ltd</rights><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-fb5a9e1a51d75c55d1eda71156d5a84afede3eebe397b3461510e9af30b80c873</citedby><cites>FETCH-LOGICAL-c461t-fb5a9e1a51d75c55d1eda71156d5a84afede3eebe397b3461510e9af30b80c873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ces.2004.10.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=16512607$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kwan, Chih Chi</creatorcontrib><creatorcontrib>Mio, Hiroshi</creatorcontrib><creatorcontrib>Qi Chen, Yong</creatorcontrib><creatorcontrib>Long Ding, Yu</creatorcontrib><creatorcontrib>Saito, Fumio</creatorcontrib><creatorcontrib>Papadopoulos, Dimitris G.</creatorcontrib><creatorcontrib>Craig Bentham, A.</creatorcontrib><creatorcontrib>Ghadiri, Mojtaba</creatorcontrib><title>Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)</title><title>Chemical engineering science</title><description>The milling behaviour of microcrystalline cellulose (MCC) and
α
-lactose monohydrate (
α
LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of
α
LM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and
α
LM is described by a first order rate process, and its rate constant,
K
p
, is found to correlate very well with the milling power,
P
n
, determined by the DEM simulation, except for the milling behaviour of
α
LM at 18
Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials.</description><subject>[formula omitted]-lactose monohydrate</subject><subject>Applied sciences</subject><subject>Chemical engineering</subject><subject>DEM simulation</subject><subject>Exact sciences and technology</subject><subject>Grinding</subject><subject>Media mill</subject><subject>Microcrystalline cellulose</subject><subject>Solid-solid systems</subject><issn>0009-2509</issn><issn>1873-4405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNp9kMtOwzAQRS0EEuXxAey8AcEiZZzESSNWqC0PiYoNbLFce0Jd5VE8Loi_x1GR2LEazejembmHsTMBYwGiuF6PDdI4BchjPwZI99hITMosyXOQ-2wEAFWSSqgO2RHROrZlKWDE3m473XyTI97XPKyQt65pXPfOvQ44zDYr7VttcBuc0Q3f9F8WPfEtDaLBMHMUXGcCnzfYYhf4AsOqt_xyNl9cnbCDWjeEp7_1mL3ezV-mD8nT8_3j9PYpMXkhQlIvpa5QaClsKY2UVqDVpRCysFJPcl2jxQxxiVlVLrNokQKw0nUGywmYGPOYXez2bnz_sUUKqnVksGl0h_2WVDqRWZbmVRSKndD4nshjrTbetdp_KwFqIKnWKpJUA8lhFElGz_nvck2RQe11Zxz9GQsp0gKGJ252OoxJPx16RcZhZ9A6jyYo27t_rvwAd8mI8A</recordid><startdate>20050301</startdate><enddate>20050301</enddate><creator>Kwan, Chih Chi</creator><creator>Mio, Hiroshi</creator><creator>Qi Chen, Yong</creator><creator>Long Ding, Yu</creator><creator>Saito, Fumio</creator><creator>Papadopoulos, Dimitris G.</creator><creator>Craig Bentham, A.</creator><creator>Ghadiri, Mojtaba</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope></search><sort><creationdate>20050301</creationdate><title>Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)</title><author>Kwan, Chih Chi ; Mio, Hiroshi ; Qi Chen, Yong ; Long Ding, Yu ; Saito, Fumio ; Papadopoulos, Dimitris G. ; Craig Bentham, A. ; Ghadiri, Mojtaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-fb5a9e1a51d75c55d1eda71156d5a84afede3eebe397b3461510e9af30b80c873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>[formula omitted]-lactose monohydrate</topic><topic>Applied sciences</topic><topic>Chemical engineering</topic><topic>DEM simulation</topic><topic>Exact sciences and technology</topic><topic>Grinding</topic><topic>Media mill</topic><topic>Microcrystalline cellulose</topic><topic>Solid-solid systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kwan, Chih Chi</creatorcontrib><creatorcontrib>Mio, Hiroshi</creatorcontrib><creatorcontrib>Qi Chen, Yong</creatorcontrib><creatorcontrib>Long Ding, Yu</creatorcontrib><creatorcontrib>Saito, Fumio</creatorcontrib><creatorcontrib>Papadopoulos, Dimitris G.</creatorcontrib><creatorcontrib>Craig Bentham, A.</creatorcontrib><creatorcontrib>Ghadiri, Mojtaba</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><jtitle>Chemical engineering science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kwan, Chih Chi</au><au>Mio, Hiroshi</au><au>Qi Chen, Yong</au><au>Long Ding, Yu</au><au>Saito, Fumio</au><au>Papadopoulos, Dimitris G.</au><au>Craig Bentham, A.</au><au>Ghadiri, Mojtaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)</atitle><jtitle>Chemical engineering science</jtitle><date>2005-03-01</date><risdate>2005</risdate><volume>60</volume><issue>5</issue><spage>1441</spage><epage>1448</epage><pages>1441-1448</pages><issn>0009-2509</issn><eissn>1873-4405</eissn><coden>CESCAC</coden><abstract>The milling behaviour of microcrystalline cellulose (MCC) and
α
-lactose monohydrate (
α
LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of
α
LM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and
α
LM is described by a first order rate process, and its rate constant,
K
p
, is found to correlate very well with the milling power,
P
n
, determined by the DEM simulation, except for the milling behaviour of
α
LM at 18
Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.ces.2004.10.002</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-2509 |
| ispartof | Chemical engineering science, 2005-03, Vol.60 (5), p.1441-1448 |
| issn | 0009-2509 1873-4405 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_28533249 |
| source | Elsevier ScienceDirect Journals |
| subjects | [formula omitted]-lactose monohydrate Applied sciences Chemical engineering DEM simulation Exact sciences and technology Grinding Media mill Microcrystalline cellulose Solid-solid systems |
| title | Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM) |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A18%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Analysis%20of%20the%20milling%20rate%20of%20pharmaceutical%20powders%20using%20the%20Distinct%20Element%20Method%20(DEM)&rft.jtitle=Chemical%20engineering%20science&rft.au=Kwan,%20Chih%20Chi&rft.date=2005-03-01&rft.volume=60&rft.issue=5&rft.spage=1441&rft.epage=1448&rft.pages=1441-1448&rft.issn=0009-2509&rft.eissn=1873-4405&rft.coden=CESCAC&rft_id=info:doi/10.1016/j.ces.2004.10.002&rft_dat=%3Cproquest_cross%3E28533249%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=28533249&rft_id=info:pmid/&rft_els_id=S0009250904007687&rfr_iscdi=true |