Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)
The milling behaviour of microcrystalline cellulose (MCC) and α -lactose monohydrate ( α LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of α LM is more strongly influenced by the milling...
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Veröffentlicht in: | Chemical engineering science 2005-03, Vol.60 (5), p.1441-1448 |
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Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The milling behaviour of microcrystalline cellulose (MCC) and
α
-lactose monohydrate (
α
LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of
α
LM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and
α
LM is described by a first order rate process, and its rate constant,
K
p
, is found to correlate very well with the milling power,
P
n
, determined by the DEM simulation, except for the milling behaviour of
α
LM at 18
Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials. |
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ISSN: | 0009-2509 1873-4405 |
DOI: | 10.1016/j.ces.2004.10.002 |