Analysis of the milling rate of pharmaceutical powders using the Distinct Element Method (DEM)

The milling behaviour of microcrystalline cellulose (MCC) and α -lactose monohydrate ( α LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of α LM is more strongly influenced by the milling...

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Veröffentlicht in:Chemical engineering science 2005-03, Vol.60 (5), p.1441-1448
Hauptverfasser: Kwan, Chih Chi, Mio, Hiroshi, Qi Chen, Yong, Long Ding, Yu, Saito, Fumio, Papadopoulos, Dimitris G., Craig Bentham, A., Ghadiri, Mojtaba
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Sprache:eng
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Zusammenfassung:The milling behaviour of microcrystalline cellulose (MCC) and α -lactose monohydrate ( α LM) in an oscillatory single ball mill has been analysed by using the Distinct Element Method (DEM). The experimental results suggest that the milling behaviour of α LM is more strongly influenced by the milling frequency as compared to MCC. A similar conclusion is also drawn from the DEM results. The milling behaviour of MCC and α LM is described by a first order rate process, and its rate constant, K p , is found to correlate very well with the milling power, P n , determined by the DEM simulation, except for the milling behaviour of α LM at 18 Hz. For the latter, there appears to be an incubation time after which the milling rate increases substantially. The results presented here provide a basis for predicting the milling behaviour of a material systematically based on the fundamental material properties and the machine dynamics without the need for extensive experiment and use of large quantities of materials.
ISSN:0009-2509
1873-4405
DOI:10.1016/j.ces.2004.10.002