The prognostic impact of a high number of peritumoral alveolar macrophages in neuroendocrine carcinoma in the lung
Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs lo...
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Veröffentlicht in: | Pathology international 2023-10, Vol.73 (10), p.497-508 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs located apart from the tumor (distant macrophages; dAMs). In 73 cases of neuroendocrine carcinoma (NEC: small cell lung carcinoma and large cell neuroendocrine carcinoma), the group that contained higher pAMs (≥86/μm
2
) revealed shorter recurrent‐free survival (RFS) than those with lower pAMs ( |
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ISSN: | 1320-5463 1440-1827 |
DOI: | 10.1111/pin.13365 |