The prognostic impact of a high number of peritumoral alveolar macrophages in neuroendocrine carcinoma in the lung

Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs lo...

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Veröffentlicht in:Pathology international 2023-10, Vol.73 (10), p.497-508
Hauptverfasser: Tanaka, Takehiko, Umemura, Shigeki, Miyoshi, Tomohiro, Nakai, Tokiko, Noritake, Osamu, Suzuki, Jun, Tane, Kenta, Samejima, Joji, Aokage, Keiju, Mimaki, Sachiyo, Tsuchihara, Katsuya, Taki, Tetsuro, Miyazaki, Saori, Watanabe, Reiko, Sakashita, Shingo, Sakamoto, Naoya, Kojima, Motohiro, Goto, Koichi, Ikeda, Norihiko, Tsuboi, Masahiro, Ishii, Genichiro
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Sprache:eng
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Zusammenfassung:Alveolar macrophages (AMs) are resident macrophages in the lungs; however, whether the number of AMs plays a role in the lung neuroendocrine tumor (NET) prognosis remains unclear. We counted the number of AMs located around the tumor (peritumoral alveolar macrophages [pAMs]) and the number of AMs located apart from the tumor (distant macrophages; dAMs). In 73 cases of neuroendocrine carcinoma (NEC: small cell lung carcinoma and large cell neuroendocrine carcinoma), the group that contained higher pAMs (≥86/μm 2 ) revealed shorter recurrent‐free survival (RFS) than those with lower pAMs (
ISSN:1320-5463
1440-1827
DOI:10.1111/pin.13365