Neuropsychiatric comorbidities and cognition in epilepsy with eyelid myoclonia: A retrospective pediatric case series

ObjectiveEpilepsy with eyelid myoclonia (EEM) is a rare epileptic syndrome classified within the Genetic Generalized Epilepsies of childhood. It is characterized by a high drug resistance, and little is known about prognostic factors and neurodevelopmental comorbidities. The aim of this study was to...

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Veröffentlicht in:Epileptic disorders 2023-10, Vol.25 (5), p.758-768
Hauptverfasser: Ballarà Petitbò, Maria, González Alguacil, Elena, Gutiérrez Delicado, Eva, Ortiz Cabrera, Nelmar Valentina, Duat Rodríguez, Anna, García Peñas, Juan José, Soto Insuga, Victor
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Sprache:eng
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Zusammenfassung:ObjectiveEpilepsy with eyelid myoclonia (EEM) is a rare epileptic syndrome classified within the Genetic Generalized Epilepsies of childhood. It is characterized by a high drug resistance, and little is known about prognostic factors and neurodevelopmental comorbidities. The aim of this study was to describe the clinical features, cognitive profile, and prognostic factors in a series of children with EEM.MethodsThis is a retrospective observational study of patients diagnosed with EEM from 2012 to 2022 in a tertiary pediatric hospital.ResultsSeventeen patients were analyzed (mean age at symptom onset 5.8 years). Neuropsychiatric comorbidities were present in 76.4% (attention deficit hyperactivity disorder 58.8%, behavioral disorder 11.8%, autism spectrum disorder 11.8%, and psychotic outbreaks 11.8%). Neurocognitive assessment was performed in 75%, revealing cognitive impairment in 66.6% (62.5% with borderline intellectual function and 37.5% with ‐IQ
ISSN:1294-9361
1950-6945
DOI:10.1002/epd2.20148