Heart valve disease in primary antiphospholipid syndrome

APS-associated heart valve disease (HVD) is well described. Nonetheless, limited data exist on clinical parameters associated with the course of primary APS (pAPS) patients with HVD. The goal of this study was to assess clinical features and related outcomes in patients with APS-associated HVD. In t...

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Veröffentlicht in:Rheumatology (Oxford, England) England), 2024-05, Vol.63 (5), p.1397-1402
Hauptverfasser: Niznik, Stanley, Rapoport, Micha J, Avnery, Orly, Kidon, Mona, Shavit, Ronen, Ellis, Martin H, Agmon-Levin, Nancy
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Sprache:eng
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Zusammenfassung:APS-associated heart valve disease (HVD) is well described. Nonetheless, limited data exist on clinical parameters associated with the course of primary APS (pAPS) patients with HVD. The goal of this study was to assess clinical features and related outcomes in patients with APS-associated HVD. In this multicentre retrospective study, we identified 33 pAPS patients with HVD (pAPS-HVD group) and compared their clinical course with 128 pAPS patients with normal heart valves on echocardiography (pAPS-control group). pAPS-HVD patients had more cerebrovascular events (56.3% vs 25%, P = 0.005) and livedo reticularis (24.2% vs 7.8%, P = 0.013) than pAPS-controls. Furthermore, catastrophic-APS (CAPS) (12.1% vs 2.4%, P = 0.034), recurrent thrombosis (33.3% vs 4.7%, P 
ISSN:1462-0324
1462-0332
1462-0332
DOI:10.1093/rheumatology/kead399