Myocardial tissue remodeling in early adult obesity and its association with regional adipose tissue distribution and ectopic fat deposits: a prospective study

Objectives To evaluate the left ventricular (LV) myocardial tissue characteristics in early adult obesity and its association with regional adipose tissue and ectopic fat deposition. Methods Forty-nine obese adults (mean body mass index: 29.9 ± 2.0 kg/m 2 ) and 44 healthy controls were prospectively...

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Veröffentlicht in:	European radiology 2024-02, Vol.34 (2), p.970-980
Hauptverfasser:	Liu, Jing, Qu, Yali, Li, Jing, He, Wenzhang, Chen, Xiaoyi, Li, Xue, Wang, Yinqiu, Tang, Hehan, Yuan, Yuan, Deng, Liping, Chen, Guoyong, Zheng, Tianying, Nie, Lisha, Zhou, Xiaoyue, Song, Bin, Tong, Nanwei, Peng, Liqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue Blood pressure Body fat Body mass Body mass index Body size Body weight loss Cardiac Cardiomyocytes Cardiovascular diseases Clinical trials Deposition Diagnostic Radiology Dyslipidemia Extracellular matrix Fibrosis Health risks Heart Hypertrophy Imaging Insulin Insulin resistance Internal Medicine Interventional Radiology Magnetic resonance imaging Medical imaging Medicine Medicine & Public Health Neuroradiology Obesity Patients Proton density (concentration) Radiology Regression analysis Risk factors Ultrasound Ventricle Weight control Weight loss
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Zusammenfassung:	Objectives To evaluate the left ventricular (LV) myocardial tissue characteristics in early adult obesity and its association with regional adipose tissue and ectopic fat deposition. Methods Forty-nine obese adults (mean body mass index: 29.9 ± 2.0 kg/m 2 ) and 44 healthy controls were prospectively studied. LV native and post-contrast T 1 values, extracellular volume fraction (ECV), regional adipose tissue (epicardial, visceral, and subcutaneous adipose tissue (EAT, VAT, and SAT)), and ectopic fat deposition (hepatic and pancreatic proton density fat fractions (H-PDFF and P-PDFF)) based on magnetic resonance imaging were compared. The association was assessed by multivariable linear regression. Results The obese participants showed reduced global ECV compared to the healthy controls ( p
ISSN:	1432-1084 0938-7994 1432-1084
DOI:	10.1007/s00330-023-10081-9