Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients
Abstract Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. Meth...
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| Veröffentlicht in: | Alcohol and alcoholism (Oxford) 2023-09, Vol.58 (5), p.472-477 |
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| creator | Shay, Jessica E S Vannier, Augustin Tsai, Stephanie Mahle, Rachel Diaz, Paige McLean Przybyszewski, Eric Challa, Prasanna K Patel, Suraj J Suzuki, Joji Schaefer, Esperance Goodman, Russell P Luther, Jay |
| description | Abstract
Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. Methods: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes. Exercise was evaluated using a questionnaire completed after an AUD diagnosis, and before evidence of liver disease. Cox regressions were used to generate hazard ratios (HRs) for the development of ALD. Results: 1987 patients met inclusion criteria. These patients were followed for an average of 10.7 years. In multivariable analyses, we found that patients that reported at least 2.5 h of moderate-high intensity exercise/week (confidence interval recommendation for exercise) were less likely to develop ALD compared to patients that did not exercise (HR: 0.26, 95%CI: 0.085–0.64, P = 0.007). Indeed, each hour of moderate-high intensity exercise was associated with progressively decreasing odds of developing ALD (HR: 0.76, 95%CI: 0.58–0.91, P = 0.02). Conversely, patients who did not engage in any moderate-high intensity exercise were more likely to develop ALD (HR: 2.76, 95%CI: 1.44–5.40, P = 0.003). Conclusions: In our cohort, patients with AUD who reported moderate-high intensity exercise showed a lower association with incidence of ALD development than patients who did not exercise.
Short Summary: In this retrospective cohort study, we investigated the impact of moderate-high intensity exercise on the development of alcohol-associated liver disease in patients with alcohol use disorder, using International Classification of Diseases 10 codes. For each hour of reported moderate-high intensity exercise patients had progressively decreasing odds of developing alcohol-associated liver disease. |
| doi_str_mv | 10.1093/alcalc/agad052 |
| format | Article |
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Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. Methods: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes. Exercise was evaluated using a questionnaire completed after an AUD diagnosis, and before evidence of liver disease. Cox regressions were used to generate hazard ratios (HRs) for the development of ALD. Results: 1987 patients met inclusion criteria. These patients were followed for an average of 10.7 years. In multivariable analyses, we found that patients that reported at least 2.5 h of moderate-high intensity exercise/week (confidence interval recommendation for exercise) were less likely to develop ALD compared to patients that did not exercise (HR: 0.26, 95%CI: 0.085–0.64, P = 0.007). Indeed, each hour of moderate-high intensity exercise was associated with progressively decreasing odds of developing ALD (HR: 0.76, 95%CI: 0.58–0.91, P = 0.02). Conversely, patients who did not engage in any moderate-high intensity exercise were more likely to develop ALD (HR: 2.76, 95%CI: 1.44–5.40, P = 0.003). Conclusions: In our cohort, patients with AUD who reported moderate-high intensity exercise showed a lower association with incidence of ALD development than patients who did not exercise.
Short Summary: In this retrospective cohort study, we investigated the impact of moderate-high intensity exercise on the development of alcohol-associated liver disease in patients with alcohol use disorder, using International Classification of Diseases 10 codes. For each hour of reported moderate-high intensity exercise patients had progressively decreasing odds of developing alcohol-associated liver disease.</description><identifier>ISSN: 0735-0414</identifier><identifier>ISSN: 1464-3502</identifier><identifier>EISSN: 1464-3502</identifier><identifier>DOI: 10.1093/alcalc/agad052</identifier><identifier>PMID: 37565935</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Alcohol Drinking - adverse effects ; Alcoholism - complications ; Alcoholism - epidemiology ; Humans ; Liver Diseases, Alcoholic - complications ; Liver Transplantation ; Retrospective Studies</subject><ispartof>Alcohol and alcoholism (Oxford), 2023-09, Vol.58 (5), p.472-477</ispartof><rights>The Author(s) 2023. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. 2023</rights><rights>The Author(s) 2023. Medical Council on Alcohol and Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c324t-de15f48af9d6e19b97315dbce223db8d1a7f039b0ae13678dbfa412cdb3902ac3</cites><orcidid>0000-0001-7799-1349 ; 0000-0002-9467-0480</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37565935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shay, Jessica E S</creatorcontrib><creatorcontrib>Vannier, Augustin</creatorcontrib><creatorcontrib>Tsai, Stephanie</creatorcontrib><creatorcontrib>Mahle, Rachel</creatorcontrib><creatorcontrib>Diaz, Paige McLean</creatorcontrib><creatorcontrib>Przybyszewski, Eric</creatorcontrib><creatorcontrib>Challa, Prasanna K</creatorcontrib><creatorcontrib>Patel, Suraj J</creatorcontrib><creatorcontrib>Suzuki, Joji</creatorcontrib><creatorcontrib>Schaefer, Esperance</creatorcontrib><creatorcontrib>Goodman, Russell P</creatorcontrib><creatorcontrib>Luther, Jay</creatorcontrib><title>Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients</title><title>Alcohol and alcoholism (Oxford)</title><addtitle>Alcohol Alcohol</addtitle><description>Abstract
Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. Methods: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes. Exercise was evaluated using a questionnaire completed after an AUD diagnosis, and before evidence of liver disease. Cox regressions were used to generate hazard ratios (HRs) for the development of ALD. Results: 1987 patients met inclusion criteria. These patients were followed for an average of 10.7 years. In multivariable analyses, we found that patients that reported at least 2.5 h of moderate-high intensity exercise/week (confidence interval recommendation for exercise) were less likely to develop ALD compared to patients that did not exercise (HR: 0.26, 95%CI: 0.085–0.64, P = 0.007). Indeed, each hour of moderate-high intensity exercise was associated with progressively decreasing odds of developing ALD (HR: 0.76, 95%CI: 0.58–0.91, P = 0.02). Conversely, patients who did not engage in any moderate-high intensity exercise were more likely to develop ALD (HR: 2.76, 95%CI: 1.44–5.40, P = 0.003). Conclusions: In our cohort, patients with AUD who reported moderate-high intensity exercise showed a lower association with incidence of ALD development than patients who did not exercise.
Short Summary: In this retrospective cohort study, we investigated the impact of moderate-high intensity exercise on the development of alcohol-associated liver disease in patients with alcohol use disorder, using International Classification of Diseases 10 codes. For each hour of reported moderate-high intensity exercise patients had progressively decreasing odds of developing alcohol-associated liver disease.</description><subject>Alcohol Drinking - adverse effects</subject><subject>Alcoholism - complications</subject><subject>Alcoholism - epidemiology</subject><subject>Humans</subject><subject>Liver Diseases, Alcoholic - complications</subject><subject>Liver Transplantation</subject><subject>Retrospective Studies</subject><issn>0735-0414</issn><issn>1464-3502</issn><issn>1464-3502</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkDtPwzAURi0EoqWwMiKPMKT1I85jRIiXVMQCc-TYN40hjYOdQPvvcZXSFcnSXc53LB2ELimZU5LzhWxUeAu5kpoIdoSmNE7iiAvCjtGUpFxEJKbxBJ15_0EIjTmjp2jCU5GInIsp2rxYDU72ENVmVWPT9tB6028xbMAp4wFL760ygfD4x_Q1dqAHBTqgymhoexz-t7VtogOocWO-wWEd5jIYTIt38sgZ_4k72Zuw8ufopJKNh4v9naH3h_u3u6do-fr4fHe7jBRncR9poKKKM1nlOgGal3nKqdClAsa4LjNNZVoRnpdEAuVJmumykjFlSpc8J0wqPkPXo7dz9msA3xdr4xU0jWzBDr5gmSCc0kSkAZ2PqHLWewdV0Tmzlm5bUFLsahdj7WJfOwyu9u6hXIM-4H95A3AzAnbo_pP9AlQBjrg</recordid><startdate>20230909</startdate><enddate>20230909</enddate><creator>Shay, Jessica E S</creator><creator>Vannier, Augustin</creator><creator>Tsai, Stephanie</creator><creator>Mahle, Rachel</creator><creator>Diaz, Paige McLean</creator><creator>Przybyszewski, Eric</creator><creator>Challa, Prasanna K</creator><creator>Patel, Suraj J</creator><creator>Suzuki, Joji</creator><creator>Schaefer, Esperance</creator><creator>Goodman, Russell P</creator><creator>Luther, Jay</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7799-1349</orcidid><orcidid>https://orcid.org/0000-0002-9467-0480</orcidid></search><sort><creationdate>20230909</creationdate><title>Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients</title><author>Shay, Jessica E S ; Vannier, Augustin ; Tsai, Stephanie ; Mahle, Rachel ; Diaz, Paige McLean ; Przybyszewski, Eric ; Challa, Prasanna K ; Patel, Suraj J ; Suzuki, Joji ; Schaefer, Esperance ; Goodman, Russell P ; Luther, Jay</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-de15f48af9d6e19b97315dbce223db8d1a7f039b0ae13678dbfa412cdb3902ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Alcohol Drinking - adverse effects</topic><topic>Alcoholism - complications</topic><topic>Alcoholism - epidemiology</topic><topic>Humans</topic><topic>Liver Diseases, Alcoholic - complications</topic><topic>Liver Transplantation</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shay, Jessica E S</creatorcontrib><creatorcontrib>Vannier, Augustin</creatorcontrib><creatorcontrib>Tsai, Stephanie</creatorcontrib><creatorcontrib>Mahle, Rachel</creatorcontrib><creatorcontrib>Diaz, Paige McLean</creatorcontrib><creatorcontrib>Przybyszewski, Eric</creatorcontrib><creatorcontrib>Challa, Prasanna K</creatorcontrib><creatorcontrib>Patel, Suraj J</creatorcontrib><creatorcontrib>Suzuki, Joji</creatorcontrib><creatorcontrib>Schaefer, Esperance</creatorcontrib><creatorcontrib>Goodman, Russell P</creatorcontrib><creatorcontrib>Luther, Jay</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alcohol and alcoholism (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shay, Jessica E S</au><au>Vannier, Augustin</au><au>Tsai, Stephanie</au><au>Mahle, Rachel</au><au>Diaz, Paige McLean</au><au>Przybyszewski, Eric</au><au>Challa, Prasanna K</au><au>Patel, Suraj J</au><au>Suzuki, Joji</au><au>Schaefer, Esperance</au><au>Goodman, Russell P</au><au>Luther, Jay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients</atitle><jtitle>Alcohol and alcoholism (Oxford)</jtitle><addtitle>Alcohol Alcohol</addtitle><date>2023-09-09</date><risdate>2023</risdate><volume>58</volume><issue>5</issue><spage>472</spage><epage>477</epage><pages>472-477</pages><issn>0735-0414</issn><issn>1464-3502</issn><eissn>1464-3502</eissn><abstract>Abstract
Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. Methods: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes. Exercise was evaluated using a questionnaire completed after an AUD diagnosis, and before evidence of liver disease. Cox regressions were used to generate hazard ratios (HRs) for the development of ALD. Results: 1987 patients met inclusion criteria. These patients were followed for an average of 10.7 years. In multivariable analyses, we found that patients that reported at least 2.5 h of moderate-high intensity exercise/week (confidence interval recommendation for exercise) were less likely to develop ALD compared to patients that did not exercise (HR: 0.26, 95%CI: 0.085–0.64, P = 0.007). Indeed, each hour of moderate-high intensity exercise was associated with progressively decreasing odds of developing ALD (HR: 0.76, 95%CI: 0.58–0.91, P = 0.02). Conversely, patients who did not engage in any moderate-high intensity exercise were more likely to develop ALD (HR: 2.76, 95%CI: 1.44–5.40, P = 0.003). Conclusions: In our cohort, patients with AUD who reported moderate-high intensity exercise showed a lower association with incidence of ALD development than patients who did not exercise.
Short Summary: In this retrospective cohort study, we investigated the impact of moderate-high intensity exercise on the development of alcohol-associated liver disease in patients with alcohol use disorder, using International Classification of Diseases 10 codes. For each hour of reported moderate-high intensity exercise patients had progressively decreasing odds of developing alcohol-associated liver disease.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>37565935</pmid><doi>10.1093/alcalc/agad052</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-7799-1349</orcidid><orcidid>https://orcid.org/0000-0002-9467-0480</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Alcohol and alcoholism (Oxford), 2023-09, Vol.58 (5), p.472-477 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Alcohol Drinking - adverse effects Alcoholism - complications Alcoholism - epidemiology Humans Liver Diseases, Alcoholic - complications Liver Transplantation Retrospective Studies |
| title | Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients |
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