Moderate-high intensity exercise associates with reduced incident alcohol-associated liver disease in high-risk patients

Abstract Background: Therapies to prevent alcohol-associated liver disease (ALD) in high-risk patients are needed. Aims: In this retrospective association study, we examined whether patients with alcohol use disorder (AUD) who reported greater exercise were less likely to develop liver disease. Methods: In this retrospective cohort study, we used the Mass General Brigham Biobank to investigate the impact of both moderate-high and light-intensity exercise on the development of ALD in patients with AUD, using clinician-provided diagnostic International Classification of Diseases 10 codes. Exercise was evaluated using a questionnaire completed after an AUD diagnosis, and before evidence of liver disease. Cox regressions were used to generate hazard ratios (HRs) for the development of ALD. Results: 1987 patients met inclusion criteria. These patients were followed for an average of 10.7 years. In multivariable analyses, we found that patients that reported at least 2.5 h of moderate-high intensity exercise/week (confidence interval recommendation for exercise) were less likely to develop ALD compared to patients that did not exercise (HR: 0.26, 95%CI: 0.085–0.64, P = 0.007). Indeed, each hour of moderate-high intensity exercise was associated with progressively decreasing odds of developing ALD (HR: 0.76, 95%CI: 0.58–0.91, P = 0.02). Conversely, patients who did not engage in any moderate-high intensity exercise were more likely to develop ALD (HR: 2.76, 95%CI: 1.44–5.40, P = 0.003). Conclusions: In our cohort, patients with AUD who reported moderate-high intensity exercise showed a lower association with incidence of ALD development than patients who did not exercise. Short Summary: In this retrospective cohort study, we investigated the impact of moderate-high intensity exercise on the development of alcohol-associated liver disease in patients with alcohol use disorder, using International Classification of Diseases 10 codes. For each hour of reported moderate-high intensity exercise patients had progressively decreasing odds of developing alcohol-associated liver disease.