Task‐Related Reorganization of Cognitive Network in Parkinson's Disease Using Electrophysiology

Background Cognitive deficits in Parkinson's disease (PD) patients are well described, however, their underlying neural mechanisms as assessed by electrophysiology are not clear. Objectives To reveal specific neural network alterations during the performance of cognitive tasks in PD patients using electroencephalography (EEG). Methods Ninety participants, 60 PD patients and 30 controls underwent EEG recording while performing a GO/NOGO task. Source localization of 16 regions of interest known to play a pivotal role in GO/NOGO task was performed to assess power density and connectivity within this cognitive network. The connectivity matrices were evaluated using a graph‐theory approach that included measures of cluster‐coefficient, degree, and global‐efficiency. A mixed‐model analysis, corrected for age and levodopa equivalent daily dose was performed to examine neural changes between PD patients and controls. Results PD patients performed worse in the GO/NOGO task (P