Estimation of antibody levels after COVID-19 vaccinations: Preliminary evidence for immune interoception

To date, 72 % of the world’s population has received at least one COVID-19 vaccination. The number of antibodies produced by some individuals is exponentially higher than in others, for various mostly unknown reasons. This variation causes great diversity in the future susceptibility to infection by the original or variants of the SARS-CoV-2 virus. The following study investigated whether individuals were able to estimate the strength of their antibody response after their COVID-19 vaccinations. 166 recently vaccinated participants provided a blood sample for determination of antibody titers. Participants were asked to estimate how many antibodies they thought they had produced, and were further asked how protected they felt from COVID-19 due to vaccination. Both self-rated antibody levels, and feelings of protection against COVID-19 were significantly related to their actual IgG spike antibody titers, after controlling for age, days since vaccination, BMI and cross vaccination. These results suggest that individuals may have a form of “immune interoception” which relates to their response to their COVID-19 vaccination. •Antibody levels after COVID-19 vaccines have wide variability between individuals•Self-predicted antibody levels correlate with actual titers after COVID-19 vaccine•Feelings of protection against COVID-19 correlate with antibody titers•These findings could not be explained by participant self-rated health•Findings potentially explained by immune interoception