NHC-mediated photocatalytic deoxygenation of alcohols for the synthesis of internal alkynes via a Csp3–Csp coupling reaction

NHC-mediated photocatalytic deoxygenation of alcohols for the synthesis of internal alkynes via a Csp3–Csp coupling reaction

NHC-mediated deoxygenation of alcohols under photocatalytic conditions is described. The process provides various alkyl radicals, which can react with 1-bromoalkyne via Csp3–Csp coupling to afford internal alkynes in moderate to good yields. The method offers a new and convenient approach to synthes...

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Veröffentlicht in:Organic & biomolecular chemistry 2023-08, Vol.21 (33), p.6693-6696
Hauptverfasser: Ma, Xueji, Wang, Liujie, Meng, Xiaoqing, Li, Wenbo, Wang, Qin, Gu, Yuke, Qiu, Lingna
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Alkynes
Chemical reactions
Coupling
Deoxygenation
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Zusammenfassung:NHC-mediated deoxygenation of alcohols under photocatalytic conditions is described. The process provides various alkyl radicals, which can react with 1-bromoalkyne via Csp3–Csp coupling to afford internal alkynes in moderate to good yields. The method offers a new and convenient approach to synthesize internal alkynes.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01066j