Expression profiles of circular RNAs in spermatozoa from aging men

Expression profiles of circular RNAs in spermatozoa from aging men

Background Advanced paternal age (APA) is associated with decreased fertility, but the mechanism underlying APA remains unknown. CircRNAs have been reported to be ideal candidate biomarkers for diagnostic and therapeutic applications in many diseases and are also involved in spermatogenesis. Hence,...

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Veröffentlicht in:Molecular biology reports 2023-10, Vol.50 (10), p.8081-8088
Hauptverfasser: Zhou, Qiao, Liu, Anming, Ji, Hui, Ji, Juan, Sun, Jingwen, Ling, Zhonghui, Li, Guangyao, Ling, Xiufeng, xu, Lu, Chen, Xiaoning
Format: Artikel
Sprache:eng
Schlagworte:
1-Phosphatidylinositol 3-kinase
Aging
AKT protein
Animal Anatomy
Animal Biochemistry
Biomedical and Life Sciences
Circular RNA
DNA repair
Genomes
Histology
Life Sciences
Meiosis
Morphology
Original Article
Recombination
Signal transduction
Sperm
Spermatogenesis
Therapeutic applications
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Zusammenfassung:Background Advanced paternal age (APA) is associated with decreased fertility, but the mechanism underlying APA remains unknown. CircRNAs have been reported to be ideal candidate biomarkers for diagnostic and therapeutic applications in many diseases and are also involved in spermatogenesis. Hence, we aimed to assess the circRNA expression profile of spermatozoa from aging men. Methods and results We recruited 6 subjects, including 3 in the younger group (men age 
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-023-08705-w