Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets
Weaning is a critical period in raising pigs. Novel animal feed additives that promote gut health and regulate immune function of piglets without antibiotics are needed. In this study, we aimed to test the ability of mesobiliverdin IXα-enriched microalgae (MBV IXα-enriched microalgae) to eliminate r...
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Veröffentlicht in: | Journal of animal physiology and animal nutrition 2023-11, Vol.107 (6), p.1368-1375 |
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creator | Liao, Tz-Shian Chen, Ching-Yi Lin, Chuan-Shun Chang, Cheng-Wei T Takemoto, Jon Y Lin, Yuan-Yu |
description | Weaning is a critical period in raising pigs. Novel animal feed additives that promote gut health and regulate immune function of piglets without antibiotics are needed. In this study, we aimed to test the ability of mesobiliverdin IXα-enriched microalgae (MBV IXα-enriched microalgae) to eliminate reliance on antibiotics to promote intestinal health in piglets. Eighty 28-day-old weaned piglets were randomly allocated to four groups each with four replicate pens and five piglets per pen. The dietary treatments were a basal diet as control (NC), basal diet plus 0.05% tylosin (PC), basal diet plus 0.1% or 0.5% MBV IXα-enriched microalgae as low (MBV-SP1) or high (MBV-SP2) dose respectively. All treated animals showed no significant differences in live weight, average daily gain and feed efficiency compared to control animals. Histological examination showed that MBV-SP1 and particularly MBV-SP2 increased the ratio of villus height to crypt depth in the jejunum and ileum compared to NC (p |
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Novel animal feed additives that promote gut health and regulate immune function of piglets without antibiotics are needed. In this study, we aimed to test the ability of mesobiliverdin IXα-enriched microalgae (MBV IXα-enriched microalgae) to eliminate reliance on antibiotics to promote intestinal health in piglets. Eighty 28-day-old weaned piglets were randomly allocated to four groups each with four replicate pens and five piglets per pen. The dietary treatments were a basal diet as control (NC), basal diet plus 0.05% tylosin (PC), basal diet plus 0.1% or 0.5% MBV IXα-enriched microalgae as low (MBV-SP1) or high (MBV-SP2) dose respectively. All treated animals showed no significant differences in live weight, average daily gain and feed efficiency compared to control animals. Histological examination showed that MBV-SP1 and particularly MBV-SP2 increased the ratio of villus height to crypt depth in the jejunum and ileum compared to NC (p < 0.05). Similarly, tylosin treatment also increased villi lengths and the ratio of villus height to crypt depth in the jejunum and ileum compared to the NC (p < 0.05). MBV-SP1 and particularly MBV-SP2 reduced the levels of inflammatory cytokines interleukin-6 and tumour necrosis factor-alpha in the small intestine. MBV-SP2 and tylosin similarly reduced the lipid peroxidation marker (TBARS value) in the duodenum and ileum. In conclusion, feed supplementation with MBV IXα-enriched microalgae improved gut health by villus height and production of immunomodulators that correlated with down-regulated secretion of inflammatory cytokines.</description><identifier>ISSN: 0931-2439</identifier><identifier>EISSN: 1439-0396</identifier><identifier>DOI: 10.1111/jpn.13867</identifier><identifier>PMID: 37539819</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Algae ; Animal feed ; Animals ; Antibiotics ; Aquatic microorganisms ; Crypts ; Cytokines ; Diet ; Digestive system ; Duodenum ; Enrichment ; Feed additives ; Feed conversion ; Feed efficiency ; Food additives ; Gastrointestinal tract ; Height ; Ileum ; Immune response ; Immunomodulation ; Immunomodulators ; Inflammation ; Interleukin 6 ; Intestine ; Jejunum ; Lipid peroxidation ; Lipids ; Microalgae ; Peroxidation ; Small intestine ; Swine ; Tylosin ; Villus ; Weaning</subject><ispartof>Journal of animal physiology and animal nutrition, 2023-11, Vol.107 (6), p.1368-1375</ispartof><rights>2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.</rights><rights>2023 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c273t-c5cf44191060725084680a81a52248bc83d1a8bd61f40cb19de2771f06dde0553</cites><orcidid>0000-0002-3397-3218 ; 0000-0002-5776-084X ; 0000-0002-5665-3671 ; 0000-0002-9879-6101 ; 0000-0001-9919-9168 ; 0000-0002-8978-4520</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37539819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liao, Tz-Shian</creatorcontrib><creatorcontrib>Chen, Ching-Yi</creatorcontrib><creatorcontrib>Lin, Chuan-Shun</creatorcontrib><creatorcontrib>Chang, Cheng-Wei T</creatorcontrib><creatorcontrib>Takemoto, Jon Y</creatorcontrib><creatorcontrib>Lin, Yuan-Yu</creatorcontrib><title>Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets</title><title>Journal of animal physiology and animal nutrition</title><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><description>Weaning is a critical period in raising pigs. Novel animal feed additives that promote gut health and regulate immune function of piglets without antibiotics are needed. In this study, we aimed to test the ability of mesobiliverdin IXα-enriched microalgae (MBV IXα-enriched microalgae) to eliminate reliance on antibiotics to promote intestinal health in piglets. Eighty 28-day-old weaned piglets were randomly allocated to four groups each with four replicate pens and five piglets per pen. The dietary treatments were a basal diet as control (NC), basal diet plus 0.05% tylosin (PC), basal diet plus 0.1% or 0.5% MBV IXα-enriched microalgae as low (MBV-SP1) or high (MBV-SP2) dose respectively. All treated animals showed no significant differences in live weight, average daily gain and feed efficiency compared to control animals. Histological examination showed that MBV-SP1 and particularly MBV-SP2 increased the ratio of villus height to crypt depth in the jejunum and ileum compared to NC (p < 0.05). Similarly, tylosin treatment also increased villi lengths and the ratio of villus height to crypt depth in the jejunum and ileum compared to the NC (p < 0.05). MBV-SP1 and particularly MBV-SP2 reduced the levels of inflammatory cytokines interleukin-6 and tumour necrosis factor-alpha in the small intestine. MBV-SP2 and tylosin similarly reduced the lipid peroxidation marker (TBARS value) in the duodenum and ileum. In conclusion, feed supplementation with MBV IXα-enriched microalgae improved gut health by villus height and production of immunomodulators that correlated with down-regulated secretion of inflammatory cytokines.</description><subject>Algae</subject><subject>Animal feed</subject><subject>Animals</subject><subject>Antibiotics</subject><subject>Aquatic microorganisms</subject><subject>Crypts</subject><subject>Cytokines</subject><subject>Diet</subject><subject>Digestive system</subject><subject>Duodenum</subject><subject>Enrichment</subject><subject>Feed additives</subject><subject>Feed conversion</subject><subject>Feed efficiency</subject><subject>Food additives</subject><subject>Gastrointestinal tract</subject><subject>Height</subject><subject>Ileum</subject><subject>Immune response</subject><subject>Immunomodulation</subject><subject>Immunomodulators</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Intestine</subject><subject>Jejunum</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Microalgae</subject><subject>Peroxidation</subject><subject>Small intestine</subject><subject>Swine</subject><subject>Tylosin</subject><subject>Villus</subject><subject>Weaning</subject><issn>0931-2439</issn><issn>1439-0396</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkU1OHDEQha0oUZiQLLgAspRNsmjwT7vbXkYjkiCBsgGJXcttV8945LYntoeIU-QsXIQz4QmEBd6Uq_TVU1U9hI4oOaH1nW624YRy2fVv0IK2XDWEq-4tWhDFacNq4QB9yHlDCO0F6d6jA94LriRVC_T3EnIcnXe3kKwL-Pzm4b6BkJxZg8WzMylqv9KAJ6i5ttaVimLwbnZBF8g41b8OBnAMWIfiRheLM7jc-ZirYIl4m-IcC2AXKl9qm8dr0L6scZzwH9DBhRXeupWHkj-id5P2GT49x0N0_f3savmzufj143z57aIxrOelMcJMbUsVJR3pmSCy7STRkmrBWCtHI7mlWo62o1NLzEiVBdb3dCKdtUCE4Ifoy5NuHe73ro41zC4b8F4HiLs8sKqomJJkj35-hW7iLtUt9pQULe2kYJX6-kTVi-WcYBq2yc063Q2UDHuXhurS8M-lyh4_K-7GGewL-d8W_giHFY_m</recordid><startdate>20231101</startdate><enddate>20231101</enddate><creator>Liao, Tz-Shian</creator><creator>Chen, Ching-Yi</creator><creator>Lin, Chuan-Shun</creator><creator>Chang, Cheng-Wei T</creator><creator>Takemoto, Jon Y</creator><creator>Lin, Yuan-Yu</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3397-3218</orcidid><orcidid>https://orcid.org/0000-0002-5776-084X</orcidid><orcidid>https://orcid.org/0000-0002-5665-3671</orcidid><orcidid>https://orcid.org/0000-0002-9879-6101</orcidid><orcidid>https://orcid.org/0000-0001-9919-9168</orcidid><orcidid>https://orcid.org/0000-0002-8978-4520</orcidid></search><sort><creationdate>20231101</creationdate><title>Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets</title><author>Liao, Tz-Shian ; Chen, Ching-Yi ; Lin, Chuan-Shun ; Chang, Cheng-Wei T ; Takemoto, Jon Y ; Lin, Yuan-Yu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c273t-c5cf44191060725084680a81a52248bc83d1a8bd61f40cb19de2771f06dde0553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Algae</topic><topic>Animal feed</topic><topic>Animals</topic><topic>Antibiotics</topic><topic>Aquatic microorganisms</topic><topic>Crypts</topic><topic>Cytokines</topic><topic>Diet</topic><topic>Digestive system</topic><topic>Duodenum</topic><topic>Enrichment</topic><topic>Feed additives</topic><topic>Feed conversion</topic><topic>Feed efficiency</topic><topic>Food additives</topic><topic>Gastrointestinal tract</topic><topic>Height</topic><topic>Ileum</topic><topic>Immune response</topic><topic>Immunomodulation</topic><topic>Immunomodulators</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Intestine</topic><topic>Jejunum</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Microalgae</topic><topic>Peroxidation</topic><topic>Small intestine</topic><topic>Swine</topic><topic>Tylosin</topic><topic>Villus</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Tz-Shian</creatorcontrib><creatorcontrib>Chen, Ching-Yi</creatorcontrib><creatorcontrib>Lin, Chuan-Shun</creatorcontrib><creatorcontrib>Chang, Cheng-Wei T</creatorcontrib><creatorcontrib>Takemoto, Jon Y</creatorcontrib><creatorcontrib>Lin, Yuan-Yu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal physiology and animal nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Tz-Shian</au><au>Chen, Ching-Yi</au><au>Lin, Chuan-Shun</au><au>Chang, Cheng-Wei T</au><au>Takemoto, Jon Y</au><au>Lin, Yuan-Yu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets</atitle><jtitle>Journal of animal physiology and animal nutrition</jtitle><addtitle>J Anim Physiol Anim Nutr (Berl)</addtitle><date>2023-11-01</date><risdate>2023</risdate><volume>107</volume><issue>6</issue><spage>1368</spage><epage>1375</epage><pages>1368-1375</pages><issn>0931-2439</issn><eissn>1439-0396</eissn><abstract>Weaning is a critical period in raising pigs. Novel animal feed additives that promote gut health and regulate immune function of piglets without antibiotics are needed. In this study, we aimed to test the ability of mesobiliverdin IXα-enriched microalgae (MBV IXα-enriched microalgae) to eliminate reliance on antibiotics to promote intestinal health in piglets. Eighty 28-day-old weaned piglets were randomly allocated to four groups each with four replicate pens and five piglets per pen. The dietary treatments were a basal diet as control (NC), basal diet plus 0.05% tylosin (PC), basal diet plus 0.1% or 0.5% MBV IXα-enriched microalgae as low (MBV-SP1) or high (MBV-SP2) dose respectively. All treated animals showed no significant differences in live weight, average daily gain and feed efficiency compared to control animals. Histological examination showed that MBV-SP1 and particularly MBV-SP2 increased the ratio of villus height to crypt depth in the jejunum and ileum compared to NC (p < 0.05). Similarly, tylosin treatment also increased villi lengths and the ratio of villus height to crypt depth in the jejunum and ileum compared to the NC (p < 0.05). MBV-SP1 and particularly MBV-SP2 reduced the levels of inflammatory cytokines interleukin-6 and tumour necrosis factor-alpha in the small intestine. MBV-SP2 and tylosin similarly reduced the lipid peroxidation marker (TBARS value) in the duodenum and ileum. In conclusion, feed supplementation with MBV IXα-enriched microalgae improved gut health by villus height and production of immunomodulators that correlated with down-regulated secretion of inflammatory cytokines.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>37539819</pmid><doi>10.1111/jpn.13867</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-3397-3218</orcidid><orcidid>https://orcid.org/0000-0002-5776-084X</orcidid><orcidid>https://orcid.org/0000-0002-5665-3671</orcidid><orcidid>https://orcid.org/0000-0002-9879-6101</orcidid><orcidid>https://orcid.org/0000-0001-9919-9168</orcidid><orcidid>https://orcid.org/0000-0002-8978-4520</orcidid></addata></record> |
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source | Wiley Online Library Journals Frontfile Complete |
subjects | Algae Animal feed Animals Antibiotics Aquatic microorganisms Crypts Cytokines Diet Digestive system Duodenum Enrichment Feed additives Feed conversion Feed efficiency Food additives Gastrointestinal tract Height Ileum Immune response Immunomodulation Immunomodulators Inflammation Interleukin 6 Intestine Jejunum Lipid peroxidation Lipids Microalgae Peroxidation Small intestine Swine Tylosin Villus Weaning |
title | Mesobiliverdin IXα-enriched microalgae feed additive eliminates reliance on antibiotic tylosin to promote intestinal health of weaning piglets |
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