The relationship of fatty acids to ischaemic heart disease and lifespan in men and women using Mendelian randomization
Abstract Background Observationally, polyunsaturated fatty acids (PUFAs) have health benefits compared with saturated fatty acids (SFAs); randomized controlled trials suggest fewer benefits. We used uni- and multi-variable Mendelian randomization to assess the association of major fatty acids and th...
Gespeichert in:
| Veröffentlicht in: | International journal of epidemiology 2023-12, Vol.52 (6), p.1845-1852 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Zusammenfassung: | Abstract
Background
Observationally, polyunsaturated fatty acids (PUFAs) have health benefits compared with saturated fatty acids (SFAs); randomized controlled trials suggest fewer benefits. We used uni- and multi-variable Mendelian randomization to assess the association of major fatty acids and their sub-species with ischaemic heart disease (IHD) overall and sex-specifically and with lifespan sex-specifically, given differing lifespan by sex.
Methods
We obtained strong (P |
|---|---|
| ISSN: | 0300-5771 1464-3685 |
| DOI: | 10.1093/ije/dyad108 |