Altitude and COVID-19 in Colombia: An updated analysis accounting for potential confounders

We assessed the relationship between the altitude of municipalities and the incidence, mortality, and fatality from COVID-19 and excess of mortality in Colombia between 2020 and 2022. We conducted an ecologic study including all 1122 municipalities in Colombia and used categories of altitude as main independent variable. We fit multivariable regression models for incidence, mortality, fatality rates, and excess of mortality controlling for several variables at municipality level. There was a higher incidence rate, similar mortality rate and lower case-fatality rate for COVID-19 during 2020–2022 in municipalities in the upper category of altitude (>=2500 masl) compared to the lower category (2500 m) compared to lowlands (