A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease

Cost-effective fluid biomarkers for tau aggregate pathology would improve the diagnostic and prognostic work-up of Alzheimer’s disease and facilitate the discovery of anti-tau therapies. We identified MTBR-tau243 as a specific marker for tau aggregate pathology that could be implemented in clinical...

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Veröffentlicht in:	Nature medicine 2023-08, Vol.29 (8), p.1912-1913
Format:	Artikel
Sprache:	eng
Schlagworte:	692/53/2421 692/699/375/132/1283 Alzheimer's disease Biomarkers Biomedical and Life Sciences Biomedicine Brain research Cancer Research Clinical medicine Clinical trials Cognitive ability Infectious Diseases Metabolic Diseases Molecular Medicine Neurodegenerative diseases Neuropathology Neurosciences Pathology Research Briefing Scientific imaging Tau protein
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Zusammenfassung:	Cost-effective fluid biomarkers for tau aggregate pathology would improve the diagnostic and prognostic work-up of Alzheimer’s disease and facilitate the discovery of anti-tau therapies. We identified MTBR-tau243 as a specific marker for tau aggregate pathology that could be implemented in clinical practice and trials.
ISSN:	1078-8956 1546-170X 1546-170X
DOI:	10.1038/s41591-023-02468-4