Role of Tim-3 in COVID-19: a potential biomarker and therapeutic target

Role of Tim-3 in COVID-19: a potential biomarker and therapeutic target

T cell immunoglobulin and mucin domain containing protein 3 (Tim-3), an immune checkpoint, is important for maintaining immune tolerance. There is increasing evidence that Tim-3 is aberrantly expressed in patients with COVID-19, indicating that it may play an important role in COVID-19. In this revi...

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Veröffentlicht in:Archives of virology 2023-08, Vol.168 (8), p.213-213, Article 213
Hauptverfasser: Ma, Haodong, Ren, Shengju, Meng, Qingpeng, Su, Boyuan, Wang, Kun, Liu, YiChen, Wang, Junpeng, Ding, Degang, Li, Xin
Format: Artikel
Sprache:eng
Schlagworte:
Antigens
Apoptosis
Binding sites
Biomarkers
Biomedical and Life Sciences
Biomedicine
COVID-19
Cytokines
Disease
Hepatitis
Immune checkpoint
Immunoglobulins
Immunological tolerance
Infections
Infectious Diseases
Kinases
Ligands
Lymphocytes
Lymphocytes T
Medical Microbiology
Proteins
Review
Severe acute respiratory syndrome coronavirus 2
Therapeutic applications
Therapeutic targets
Tumor necrosis factor-TNF
Tumors
Viral infections
Virology
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Zusammenfassung:T cell immunoglobulin and mucin domain containing protein 3 (Tim-3), an immune checkpoint, is important for maintaining immune tolerance. There is increasing evidence that Tim-3 is aberrantly expressed in patients with COVID-19, indicating that it may play an important role in COVID-19. In this review, we discuss the altered expression and potential role of Tim-3 in COVID-19. The expression of Tim-3 and its soluble form (sTim-3) has been found to be upregulated in COVID-19 patients. The levels of Tim-3 on T cells and circulating sTim-3 have been shown to be associated with the severity of COVID-19, suggesting that this protein could be a potential biomarker of COVID-19. Moreover, this review also highlights the potential of Tim-3 as a therapeutic target of COVID-19.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-023-05842-2