Associations of Glucose Metabolism Status with Brain Macrostructure and Microstructure: Findings from the UK Biobank

Associations of Glucose Metabolism Status with Brain Macrostructure and Microstructure: Findings from the UK Biobank

Abstract Context Evidence linking glucose metabolism status with brain macro- and microstructure is limited and inconsistent. Objective We aim to investigate the associations of glucose metabolism status with brain macrostructure and microstructure, including brain volumes, subcortical gray matter v...

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Veröffentlicht in:The journal of clinical endocrinology and metabolism 2023-12, Vol.109 (1), p.e234-e242
Hauptverfasser: Li, Ruyi, Geng, Tingting, Li, Lin, Lu, Qi, Li, Rui, Chen, Xue, Ou, Yunjing, Liu, Sen, Lin, Xiaoyu, Tian, Qingying, Qiu, Zixin, Zhu, Kai, Tang, Ziyue, Yang, Kun, Pan, An, Liu, Gang
Format: Artikel
Sprache:eng
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Zusammenfassung:Abstract Context Evidence linking glucose metabolism status with brain macro- and microstructure is limited and inconsistent. Objective We aim to investigate the associations of glucose metabolism status with brain macrostructure and microstructure, including brain volumes, subcortical gray matter volumes, and white matter microstructural metrics. Methods This study enrolled 29 251 participants from the UK Biobank. Glucose metabolism status was classified into normal glucose metabolism (NGM), prediabetes, type 2 diabetes (T2D) with HbA1c
ISSN:0021-972X
1945-7197
DOI:10.1210/clinem/dgad442