Optical coherence tomography angiography characteristics of retinochoroidal and optic nerve head microcirculation in cryptogenic organizing pneumonia

•Because of the extensive microvascular networks of the retina, choroid, and optic nerve head, these tissues are involved in a wide range of systemic diseases, including cryptogenic organizing pneumonia.•Cryptogenic organizing pneumonia appears to cause general declines in superficial and deep capillary plexus vessel densities, but enhanced capillary flow in the outer retina and choriocapillaris.•Rather than reduced choroidal microcirculation, cryptogenic organizing pneumonia patients appear to have lower retinal perfusion.•Despite having lower vessel densities in the majority of optic nerve head quadrants, the total retinal nerve fiber layer thickness was larger.•In cryptogenic organizing pneumonia, increased oxidative stress and hypoxia could impair ocular structures. To assess retinochoroidal and optic nerve head microcirculation alterations in cryptogenic organizing pneumonia. Thirty cryptogenic organizing pneumonia patients in the resolution phase (group 1, 30 right eyes) and 33 healthy subjects (group 2, 33 right eyes) were compared. Patients had 40 mg/day corticosteroids for 8–10 days, and a pulmonary function test, which revealed only minimally restrictive ventilation features. After gathering demographic data, a comprehensive ophthalmological exam and optical coherence tomography angiography were performed three months following maximum disease resolution with corticosteroid therapy Groups 1 and 2 had mean ages of 54.37±14.87 and 49.61±12.36 years, respectively (P = 0.171). Despite the lack of statistical significance, superficial and deep capillary plexus vessel densities in all macular regions were lower in group 1, as were foveal avascular zone parameters (P>0.05). However, the outer retinal and choriocapillaris flows increased significantly in group 1, especially in select areas (P