Motion-resolved four-dimensional abdominal diffusion-weighted imaging using PROPELLER EPI (4D-DW-PROPELLER-EPI)

To develop a distortion-free motion-resolved four-dimensional diffusion-weighted PROPELLER EPI (4D-DW-PROPELLER-EPI) technique for benefiting clinical abdominal radiotherapy (RT). An improved abdominal 4D-DWI technique based on 2D diffusion-weighted PROPELLER-EPI (2D-DW-PROPELLER-EPI), termed 4D-DW-PROPELLER-EPI, was proposed to improve the frame rate of repeated data acquisition and produce distortion-free 4D-DWI images. Since the radial or PROPELLER sampling with golden-angle rotation can achieve an efficient k-space coverage with a flexible time-resolved acquisition, the golden-angle multi-blade acquisition was used in the proposed 4D-DW-PROPELLER-EPI to improve the performance of data sorting. A new k-space and blade (K-B) amplitude binning method was developed for the proposed 4D-DW-PROPELLER-EPI to optimize the number of blades and the k-space uniformity before performing conventional PROPELLER-EPI reconstruction, by using two metrics to evaluate the adequacy of the acquired data. The proposed 4D-DW-PROPELLER-EPI was preliminarily evaluated in both simulation experiments and in vivo experiments with varying frame rates and different numbers of repeated acquisition. The feasibility of achieving distortion-free 4D-DWI images by using the proposed 4D-DW-PROPELLER-EPI technique was demonstrated in both digital phantom and healthy subjects. Evaluation of the 4D completeness metrics shows that the K-B amplitude binning method could simultaneously improve the acquisition efficiency and data reconstruction performance for 4D-DW-PROPELLER-EPI. 4D-DW-PROPELLER-EPI with K-B amplitude binning is an advanced technique that can provide distortion-free 4D-DWI images for resolving respiratory motion, and may benefit the application of image-guided abdominal RT.