Elevated mean arterial pressure is associated with a lower risk of mortality in acute kidney injury patients receiving continuous renal replacement therapy

This study explored the relationship between mean arterial pressure and the risk of mortality in patients with acute kidney injury receiving continuous renal replacement therapy. Elevated mean arterial pressure is associated with a lower risk of mortality in acute kidney injury patients receiving continuous renal replacement therapy. maintenance of an appropriate mean arterial pressure (MAP) is important for critically ill patients. However, the association between MAP and prognosis in acute kidney injury (AKI) patients receiving continuous renal replacement therapy (CRRT) is thus far unclear. a total of 1,144 AKI patients who had received CRRT between January 2009 and September 2016 were enrolled and their MAP was measured at CRRT initiation. Patients were categorized into four groups (Quartile 1: MAP < 67.3 mmHg; Quartile 2: 67.3 ≤ MAP < 76.7 mmHg; Quartile 3: 76.7 ≤ MAP < 86.3 mmHg; Quartile 4: MAP ≥ 86.3 mmHg), and 28- and 90-day mortality rates were compared. our results demonstrate that 204 (72.1%), 187 (63.4%), 174 (62.6%), and 145 (50.3%) deaths occurred in quartiles 1, 2, 3, and 4 within 28 days, respectively (p