Retromode Imaging Technology for Detecting Drusen-Like Deposits in Healthy Adults

To investigate the ability of retromode imaging technology to visualize drusen-like deposits (DLDs) in the macular region of healthy individuals without retinal diseases. Additionally, the correlation between subject age and the density of DLDs was assessed and their topographic distribution was evaluated. Prospective, observational, cross-sectional study Healthy volunteers (age ≥35 years) without macular diseases. This study evaluated macular images in healthy adults using color fundus photography (FP) and retromode imaging. Two masked graders counted the number of DLDs identifiable with each modality. The standardized early treatment diabetic retinopathy study (ETDRS) concentric rings were adopted to divide DLDs based on their topographic distribution. Comparison of the number of DLDs detected with each imaging modality. The association between DLDs and age. The topographic distribution of macular DLDs with retromode imaging. The study included 91 eyes of 52 healthy volunteers (mean age, 57.9±10.9 years; range, 36-82 years). Overall, at least one DLD was present in 63.74% of eyes on color FP and 96.71% on retromode. Retromode imaging allowed detection of significantly more DLDs compared to color fundus photography within the ETDRS grid (median [interquartile range], 4[1-14] vs 0[0-0] respectively, P