A Core-Shell Nanoreinforced Ion-Conductive Implantable Hydrogel Bioelectronic Patch with High Sensitivity And Bioactivity for Real-Time Synchronous Heart Monitoring And Repairing

To achieve synchronous repair and real-time monitoring the infarcted myocardium based on an integrated ion-conductive hydrogel patch is challenging yet intriguing. Herein, w e report a novel synthetic strategy based on core-shell-structured curcumin nanocomposite reinforced ion-conductive hydrogel for synchronous heart electrophysiological signal monitoring and infarcted heart repair. The nanoreinforcement and multisite cross-linking of bioactive curcumin nanoparticles enable well elasticity with negligible hysteresis, implantability, ultra-high mechanoelectrical sensitivity (37 ms) and reliable sensing capacity (over 5000 cycles) for the nanoreinforced hydrogel. Results of in vitro and in vivo experiments demonstrated that such solely physical microenvironment of electrophysiological and biomechanical characteristics combing with the role of bioactive curcumin exert the synchronous benefit of regulating inflammatory microenvironment, promoting angiogenesis and reducing myocardial fibrosis for effective MI repair. Especially, o ur hydrogel sensors offer the access for achieving accurate acquisition of cardiac signals, thus monitoring the whole MI healing process. This novel bioactive and electrophysiological-sensing ion-conductive hydrogel cardiac patch highlights a versatile strategy promising for synchronous integration of in vivo real-time monitor the MI status and excellent MI repair performance. This article is protected by copyright. All rights reserved.