Predicting Limited Survival Following Inguinal Lymph Node Dissection in Penile Cancer: Should we revisit the goals of care?

Patients with advanced penile squamous cell cancer (pSCC) have a poor prognosis and can benefit from early palliative care consultation. We built a model to identify those patients most likely to benefit. Patients with pSCC undergoing inguinal lymph node dissection (ILND) were identified from the National Cancer Database (NCDB) and a multi-institutional international dataset (INT). A multivariable Cox proportional hazards model for OS was developed using the NCDB and applied to the INT dataset. Parameters were used to make ROC curves. ROC-related criteria were optimized to identify a predictive probability cut point and dichotomize patients from INT into risk groups for limited OS of