Production of polyhydroxyalkanoates as a feasible alternative for an integrated multiproduct lignocellulosic biorefinery

[Display omitted] •PHAs are biodegradable, biocompatible, non-toxic and thermoplastic.•High PHA production costs are the main constraint for its industrialization.•Lignocellulosic biomass is a renewable and cheaper feedstock for PHA synthesis.•PHA from lignocellulosic biomass is a feasible and sustainable alternative.•Full integration of PHA into a lignocellulosic biorefinery is getting closer. Polyhydroxyalkanoates (PHAs) are considered an alternative to fossil fuel-based plastics. However, in spite of their interesting properties and their multiple applications, PHAs have not taken off as an industrial development. The reason is mainly due to the associated high-production costs, which represent a significant constraint. In recent years, the interest in lignocellulosic biomass (LCB) derived from crop, forestry or municipal waste by-products has been growing, since LCB is plentiful, cheap, renewable and sustainable. On this matter, the valorization of LCB into PHAs represents a promising route within circular economy strategies. However, much effort still needs to be made to improve the bioconversion yields and to enhance PHA production efficiency. So, this review focuses on reviewing the different options for PHA synthesis from LCB, stressing the progress in biomass deconstruction, enzymatic hydrolysis and microbial conversion. In addition, some of the current biological strategies for improving the process of bioconversion are discussed.