Are GLP-1R agonists the long-sought-after panacea for obesity?

Are GLP-1R agonists the long-sought-after panacea for obesity?

Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists are hugely effective in the treatment of obesity. Originally developed for type 2 diabetes (T2D), these drugs cause dramatic weight loss in people with overweight or obesity, but how do they work, and are these therapeutics the long-sought-a...

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Veröffentlicht in:Trends in molecular medicine 2023-10, Vol.29 (10), p.777-779
Hauptverfasser: Dowsett, Georgina K.C., Yeo, Giles S.H.
Format: Artikel
Sprache:eng
Schlagworte:
brain
GLP-1R
obesity
therapeutics
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Zusammenfassung:Glucagon-like peptide 1 (GLP-1) receptor (GLP-1R) agonists are hugely effective in the treatment of obesity. Originally developed for type 2 diabetes (T2D), these drugs cause dramatic weight loss in people with overweight or obesity, but how do they work, and are these therapeutics the long-sought-after solution to obesity? Here we explain the mechanisms of action of GLP-1R agonists in the context of weight loss and discuss their importance as therapeutics for obesity treatment.
ISSN:1471-4914
1471-499X
1471-499X
DOI:10.1016/j.molmed.2023.06.008