Molecular mechanism of GPCR spatial organization at the plasma membrane

G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their spatial organization in plasma membrane (PM) domains is believed to encode signaling specificity and efficiency. However, the existence of domains and, crucially, the mechanism of formation of such putative doma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2024-02, Vol.20 (2), p.142-150
Hauptverfasser:	Kockelkoren, Gabriele, Lauritsen, Line, Shuttle, Christopher G., Kazepidou, Eleftheria, Vonkova, Ivana, Zhang, Yunxiao, Breuer, Artù, Kennard, Celeste, Brunetti, Rachel M., D’Este, Elisa, Weiner, Orion D., Uline, Mark, Stamou, Dimitrios
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/245 631/1647/328 631/57 631/80/313 631/92/612/194 Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Cell Membrane - metabolism Chemistry Chemistry and Materials Science Chemistry/Food Science Curvature G protein-coupled receptors Growth factors H-Ras protein Imaging Medical innovations Membrane proteins Membranes Molecular modelling Plasma Proteins Receptors Receptors, G-Protein-Coupled - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	G-protein-coupled receptors (GPCRs) mediate many critical physiological processes. Their spatial organization in plasma membrane (PM) domains is believed to encode signaling specificity and efficiency. However, the existence of domains and, crucially, the mechanism of formation of such putative domains remain elusive. Here, live-cell imaging (corrected for topography-induced imaging artifacts) conclusively established the existence of PM domains for GPCRs. Paradoxically, energetic coupling to extremely shallow PM curvature (
ISSN:	1552-4450 1552-4469 1552-4469
DOI:	10.1038/s41589-023-01385-4