Unusual Selective Monitoring of N,N-Dimethylformamide in a Two-Dimensional Material Field-Effect Transistor

N,N-Dimethylformamide (DMF) is an essential solvent in industries and pharmaceutics. Its market size range was estimated to be 2 billion U.S. dollars in 2022. Monitoring DMF in solution environments in real time is significant because of its toxicity. However, DMF is not a redox-active molecule; the...

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Veröffentlicht in:ACS nano 2023-08, Vol.17 (15), p.14981-14989
Hauptverfasser: Fukui, Akito, Matsuyama, Keigo, Onoe, Hiroaki, Itai, Shun, Ikeno, Hidekazu, Hiraoka, Shunsuke, Hiura, Kousei, Hijikata, Yuh, Pirillo, Jenny, Nagata, Takahiro, Takei, Kuniharu, Yoshimura, Takeshi, Fujimura, Norifumi, Kiriya, Daisuke
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Sprache:eng
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Zusammenfassung:N,N-Dimethylformamide (DMF) is an essential solvent in industries and pharmaceutics. Its market size range was estimated to be 2 billion U.S. dollars in 2022. Monitoring DMF in solution environments in real time is significant because of its toxicity. However, DMF is not a redox-active molecule; therefore, selective monitoring of DMF in solutions, especially in polar aqueous solutions, in real time is extremely difficult. In this paper, we propose a selective DMF sensor using a molybdenum disulfide (MoS2) field-effect transistor (FET). The sensor responds to DMF molecules but not to similar molecules of formamide, N,N-diethylformamide, and N,N-dimethylacetamide. The plausible atomic mechanism is the oxygen substitution sites on MoS2, on which the DMF molecule shows an exceptional orientation. The thin structure of MoS2–FET can be incorporated into a microfluidic chamber, which leads to DMF monitoring in real time by exchanging solutions subsequently. The designed device shows DMF monitoring in NaCl ionic solutions from 1 to 200 μL/mL. This work proposes the concept of selectively monitoring redox-inactive molecules based on the nonideal atomic affinity site on the surface of two-dimensional semiconductors.
ISSN:1936-0851
1936-086X
DOI:10.1021/acsnano.3c03915