Green synthesis of nanolipo-fibersomes using Nutriose® FB 06 for delphinidin-3-O-sambubioside delivery: Characterization, physicochemical properties, and application

Anthocyanins are potential bioactive compounds with less bioavailability due to instability in physicochemical and physiological harsh environments. This study synthesized a “nanolipo-fibersomes (NLFS)” using Lipoid® S75 and Nutriose® FB 06 (dextrinization of wheat starch) through a self-assembly technique with probe sonication. We aimed to encapsulate delphinidin-3-O-sambubioside (D3S) successfully and evaluate physicochemical and controlled release properties with improved antioxidant activity on palmitic acid (PA)-induced colonic cells (Caco-2 cells). D3S-loaded nanolipo-fibersomes (D3S-NLFS) were nanosized (90 %.•D3S-NLFS exerted better physicochemical stability than D3S-nanoliposomes (NL).•Higher mucoadhesive properties and cellular uptake were found for D3S-NLFS.•D3S-NLFS showed improved antioxidant activities on PA-induced Caco-2 cells.