Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio and Cardiorenal Syndrome Type 2 in the Systemic Sclerosis EUSTAR Cohort

Objective The aim of the study was to evaluate the association between the tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP) ratio and estimated glomerular filtration rate (eGFR) and their association with mortality in the European Scleroderma Trials and Re...

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Veröffentlicht in:Arthritis care & research (2010) 2025-02, Vol.77 (2), p.257-265
Hauptverfasser: Colalillo, Amalia, Pellicano, Chiara, Hachulla, Eric, Cuomo, Giovanna, Györfi, Andrea‐Hermina, Czirják, László, Vries‐Bouwstra, Jeska, Mouthon, Luc, Poormoghim, Hadi, Del Galdo, Francesco, Hunzelmann, Nicolas, Spierings, Julia, Kuwana, Masataka, Rosato, Edoardo, Gigante, Antonietta, Alunni Fegatelli, Danilo, Launay, David, Di Vico, Claudio, Bergmann, Christina, Varju, Cecilia, Scherer, HU, Chaigne, Benjamin, Andalib, Elham, Alcacer‐Pitarch, Begonya, Moinzadeh, Pia, Van Laar, Jacob, Distler, Oliver, Jordan, Suzana, Riemekasten, Gabriela, Marschner, Gabriele, Martin, Maria, Siegert, Elise, Kedor, Claudia, Simeón‐Aznar, Carmen‐Pilar, Del Castillo, Alfredo Guillén, Marcoccia, Antonella, Gabrielli, Armando, Martin, Mickaël, Landron, Cédric, Smith, Vanessa, Airò, Paolo, Lazzaroni, Maria‐Grazia, Adler, Sabine, Iannone, Florenzo, Idolazzi, Luca, Müller‐Ladner, Ulf, Alegre‐Sancho, Juan Jose, Truchetet, Marie‐Elise, Dagna, Lorenzo, Matucci Cerinic, Marco, Gheorghiu, Ana Maria, Ramazan, Ana‐Maria, Cauli, Alberto, Castellví, Ivan, Iudici, Michele, Solanki, Kamal, Soukup, Tomas, Allanore, Yannick, Limonta, Massimiliano, Pârvu, Magda, Moroncini, Gianluca, Zanatta, Elisabetta, Selvi, Enrico, Tanaka, Yoshiya, Bielecka, Otylia Kowal, Cutolo, Maurizio, Rednic, Simona, Henes, Jörg, Kahl, Sarah, Del Papa, Nicoletta, Denton, Christopher, Schmeiser, Tim, Brzosko, Marek, Sfikakis, Petros, Walker, Ulrich, Negrini, Simone, Riccieri, Valeria, Radic, Mislav, Heitmann, Stefan, Cantatore, Francesco Paolo, Souza Müller, Carolina, Foti, Rosario, Couto, Maura, Rezus, Elena, Balbir‐Gurman, Alexandra, Krasowska, Dorota, Opris‐Belinski, Daniela, Aringer, Martin, Anic, Branimir, Baresic, Marko, Mayer, Miroslav, Yavuz, Sule, Agachi, Svetlana, Oksel, Fahrettin, Zdrojewski, Zbigniew, Rodriguez‐Pinto, Ignasi, Geroldinger‐Simic, Marija, Lledó‐Ibañez, Gema Maria, Kubacki, Torsten, Batalov, Anastas
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Zusammenfassung:Objective The aim of the study was to evaluate the association between the tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP) ratio and estimated glomerular filtration rate (eGFR) and their association with mortality in the European Scleroderma Trials and Research (EUSTAR) cohort. Methods Patients with systemic sclerosis (SSc) from the EUSTAR database with TAPSE, sPAP, and parameters required to calculate eGFR were included. Logistic regression and Cox regression analysis were performed to evaluate TAPSE/sPAP as a risk factor for chronic kidney disease (CKD) and overall survival. Results A total of 2,370 patients with SSc were included; 284 (12%) patients had CKD stage 3a–5. TAPSE/sPAP (odds ratio [OR] 0.479; 95% CI 0.310–0.743; P
ISSN:2151-464X
2151-4658
DOI:10.1002/acr.25196