Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting
Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity...
Gespeichert in:
| Veröffentlicht in: | Med (New York, N.Y. : Online) N.Y. : Online), 2023-07, Vol.4 (7), p.398-400 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 400 |
|---|---|
| container_issue | 7 |
| container_start_page | 398 |
| container_title | Med (New York, N.Y. : Online) |
| container_volume | 4 |
| creator | Lakes, Nora Canaday, Laura M. Waggoner, Stephen N. |
| description | Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.
Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes. |
| doi_str_mv | 10.1016/j.medj.2023.06.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2838254715</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S2666634023001964</els_id><sourcerecordid>2838254715</sourcerecordid><originalsourceid>FETCH-LOGICAL-c351t-66cc960f763f84cd94d75d97e3570760e9c7bd9e61480a0a0a86d7e3fd81458c3</originalsourceid><addsrcrecordid>eNp9kE1OwzAQhS0Eoqj0AiyQl2WR1I4dJ0FsSsRPpSJYwA7Jcu1Jm6hNiu1WYsc1uB4nIVELYoVmMaOZ9540H0JnlISUUDGqwhWYKoxIxEIiQkKyA3QSCSECwTg5_DP30MC5ihASxZTRLDpGPZbwmHHKT9Brruqvj0-PjW3W2C8AP0zy4Xh0fXGJnyxsofZlPcfOW3AuWJZzVRvsFmBMt_YNhnqhag14repAd5PFXtk5dLZTdFSopYPBvvfRy-3Nc34fTB_vJvl4GmgWUx8IoXUmSJEIVqRcm4ybJDZZAixOSCIIZDqZmQwE5SlRXaXCtNfCpJTHqWZ9NNzlrm3ztgHn5ap0GpZLVUOzcTJKWRrFPKFxK412Um0b5ywUcm3LlbLvkhLZgZWV7MDKDqwkQrZgW9P5Pn8za4-_lh-MreBqJ4D2y20JVjpdQgvDlBa0l6Yp_8v_BtTyiMs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2838254715</pqid></control><display><type>article</type><title>Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Lakes, Nora ; Canaday, Laura M. ; Waggoner, Stephen N.</creator><creatorcontrib>Lakes, Nora ; Canaday, Laura M. ; Waggoner, Stephen N.</creatorcontrib><description>Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.
Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.</description><identifier>ISSN: 2666-6340</identifier><identifier>EISSN: 2666-6340</identifier><identifier>DOI: 10.1016/j.medj.2023.06.009</identifier><identifier>PMID: 37453414</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Cell Membrane - pathology ; Humans ; Immunotherapy, Adoptive ; Killer Cells, Natural - metabolism ; Killer Cells, Natural - pathology ; Ligands ; Neoplasms - therapy</subject><ispartof>Med (New York, N.Y. : Online), 2023-07, Vol.4 (7), p.398-400</ispartof><rights>2023 Elsevier Inc.</rights><rights>Copyright © 2023 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c351t-66cc960f763f84cd94d75d97e3570760e9c7bd9e61480a0a0a86d7e3fd81458c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37453414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lakes, Nora</creatorcontrib><creatorcontrib>Canaday, Laura M.</creatorcontrib><creatorcontrib>Waggoner, Stephen N.</creatorcontrib><title>Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting</title><title>Med (New York, N.Y. : Online)</title><addtitle>Med</addtitle><description>Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.
Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.</description><subject>Cell Membrane - pathology</subject><subject>Humans</subject><subject>Immunotherapy, Adoptive</subject><subject>Killer Cells, Natural - metabolism</subject><subject>Killer Cells, Natural - pathology</subject><subject>Ligands</subject><subject>Neoplasms - therapy</subject><issn>2666-6340</issn><issn>2666-6340</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1OwzAQhS0Eoqj0AiyQl2WR1I4dJ0FsSsRPpSJYwA7Jcu1Jm6hNiu1WYsc1uB4nIVELYoVmMaOZ9540H0JnlISUUDGqwhWYKoxIxEIiQkKyA3QSCSECwTg5_DP30MC5ihASxZTRLDpGPZbwmHHKT9Brruqvj0-PjW3W2C8AP0zy4Xh0fXGJnyxsofZlPcfOW3AuWJZzVRvsFmBMt_YNhnqhag14repAd5PFXtk5dLZTdFSopYPBvvfRy-3Nc34fTB_vJvl4GmgWUx8IoXUmSJEIVqRcm4ybJDZZAixOSCIIZDqZmQwE5SlRXaXCtNfCpJTHqWZ9NNzlrm3ztgHn5ap0GpZLVUOzcTJKWRrFPKFxK412Um0b5ywUcm3LlbLvkhLZgZWV7MDKDqwkQrZgW9P5Pn8za4-_lh-MreBqJ4D2y20JVjpdQgvDlBa0l6Yp_8v_BtTyiMs</recordid><startdate>20230714</startdate><enddate>20230714</enddate><creator>Lakes, Nora</creator><creator>Canaday, Laura M.</creator><creator>Waggoner, Stephen N.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20230714</creationdate><title>Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting</title><author>Lakes, Nora ; Canaday, Laura M. ; Waggoner, Stephen N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-66cc960f763f84cd94d75d97e3570760e9c7bd9e61480a0a0a86d7e3fd81458c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cell Membrane - pathology</topic><topic>Humans</topic><topic>Immunotherapy, Adoptive</topic><topic>Killer Cells, Natural - metabolism</topic><topic>Killer Cells, Natural - pathology</topic><topic>Ligands</topic><topic>Neoplasms - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lakes, Nora</creatorcontrib><creatorcontrib>Canaday, Laura M.</creatorcontrib><creatorcontrib>Waggoner, Stephen N.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Med (New York, N.Y. : Online)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lakes, Nora</au><au>Canaday, Laura M.</au><au>Waggoner, Stephen N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting</atitle><jtitle>Med (New York, N.Y. : Online)</jtitle><addtitle>Med</addtitle><date>2023-07-14</date><risdate>2023</risdate><volume>4</volume><issue>7</issue><spage>398</spage><epage>400</epage><pages>398-400</pages><issn>2666-6340</issn><eissn>2666-6340</eissn><abstract>Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.
Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>37453414</pmid><doi>10.1016/j.medj.2023.06.009</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2666-6340 |
| ispartof | Med (New York, N.Y. : Online), 2023-07, Vol.4 (7), p.398-400 |
| issn | 2666-6340 2666-6340 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2838254715 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Cell Membrane - pathology Humans Immunotherapy, Adoptive Killer Cells, Natural - metabolism Killer Cells, Natural - pathology Ligands Neoplasms - therapy |
| title | Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-13T12%3A46%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Can%E2%80%99t%20drop%20the%20MIC(A/B):%20Preventing%20stress-ligand%20shedding%20to%20enhance%20pan-cancer%20targeting&rft.jtitle=Med%20(New%20York,%20N.Y.%20:%20Online)&rft.au=Lakes,%20Nora&rft.date=2023-07-14&rft.volume=4&rft.issue=7&rft.spage=398&rft.epage=400&rft.pages=398-400&rft.issn=2666-6340&rft.eissn=2666-6340&rft_id=info:doi/10.1016/j.medj.2023.06.009&rft_dat=%3Cproquest_cross%3E2838254715%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2838254715&rft_id=info:pmid/37453414&rft_els_id=S2666634023001964&rfr_iscdi=true |