Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting

Can’t drop the MIC(A/B): Preventing stress-ligand shedding to enhance pan-cancer targeting

Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity...

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Veröffentlicht in:Med (New York, N.Y. : Online) N.Y. : Online), 2023-07, Vol.4 (7), p.398-400
Hauptverfasser: Lakes, Nora, Canaday, Laura M., Waggoner, Stephen N.
Format: Artikel
Sprache:eng
Schlagworte:
Cell Membrane - pathology
Humans
Immunotherapy, Adoptive
Killer Cells, Natural - metabolism
Killer Cells, Natural - pathology
Ligands
Neoplasms - therapy
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Zusammenfassung:Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes. Chimeric antigen receptor (CAR)-based cellular therapies have achieved remarkable success against hematologic malignancies, but their application against solid tumors remains challenging. In this issue, Goulding et al.1 describe a unique CAR natural killer (NK) cell platform with pan-cancer activity via preservation and recognition of stress ligands on tumor cell membranes.
ISSN:2666-6340
2666-6340
DOI:10.1016/j.medj.2023.06.009