Identification of B-cell-related HSPG2 and CDSN as susceptibility loci for Kawasaki disease

Identification of B-cell-related HSPG2 and CDSN as susceptibility loci for Kawasaki disease

Kawasaki disease (KD) is an acute pediatric vasculitis that predominantly affects children under the age of 5 years. To date, genome-wide association studies (GWAS) have identified several KD susceptibility genes (e.g., BLK, CD40, FCGR2A, BCL2L11, and IGHV), which are mainly involved in B cell immun...

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Veröffentlicht in:Human immunology 2023-10, Vol.84 (10), p.567-570
Hauptverfasser: Kim, Jae-Jung, Hong, Young Mi, Yun, Sin Weon, Lee, Kyung-Yil, Yoon, Kyung Lim, Han, Myung-Ki, Kim, Gi Beom, Kil, Hong-Ryang, Song, Min Seob, Lee, Hyoung Doo, Ha, Kee Soo, Jun, Hyun Ok, Yu, Jeong Jin, Jang, Gi Young, Lee, Jong-Keuk
Format: Artikel
Sprache:eng
Schlagworte:
Association study
B-cell-related genes
Kawasaki disease
Susceptibility
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Zusammenfassung:Kawasaki disease (KD) is an acute pediatric vasculitis that predominantly affects children under the age of 5 years. To date, genome-wide association studies (GWAS) have identified several KD susceptibility genes (e.g., BLK, CD40, FCGR2A, BCL2L11, and IGHV), which are mainly involved in B cell immunity. In this study, we aimed to identify additional KD susceptibility genes mainly involved in B cell development and functions by analyzing our previous GWAS data and conducting a replication study using new sample. Initially, we selected 30 single nucleotide polymorphisms (SNPs) in B-cell-related genes that were significantly (P 
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2023.07.001