Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience

Prognostic factors for pediatric, adolescent, and young adult patients with non-DIPG grade 4 gliomas: a contemporary pooled institutional experience

Purpose WHO grade 4 gliomas are rare in the pediatric and adolescent and young adult (AYA) population. We evaluated prognostic factors and outcomes in the pediatric versus AYA population. Methods This retrospective pooled study included patients less than 30 years old (yo) with grade 4 gliomas treat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of neuro-oncology 2023-07, Vol.163 (3), p.717-726
Hauptverfasser: Matsui, Jennifer K., Allen, Pamela K., Perlow, Haley K., Johnson, Jason M., Paulino, Arnold C., McAleer, Mary Frances, Fouladi, Maryam, Grosshans, David R., Ghia, Amol J., Li, Jing, Zaky, Wafik T., Chintagumpala, Murali M., Palmer, Joshua D., McGovern, Susan L.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Age
Biopsy
Brain Neoplasms - diagnosis
Brain Neoplasms - therapy
Case Study
Child
Female
Glioblastoma
Glioma
Glioma - diagnosis
Glioma - therapy
Humans
Medical prognosis
Medicine
Medicine & Public Health
Multivariate analysis
Neurology
Oncology
Patients
Pediatrics
Population studies
Prognosis
Prospective Studies
Radiation therapy
Retrospective Studies
Surgery
Survival
Toxicity
Tumors
Young Adult
Young adults
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Purpose WHO grade 4 gliomas are rare in the pediatric and adolescent and young adult (AYA) population. We evaluated prognostic factors and outcomes in the pediatric versus AYA population. Methods This retrospective pooled study included patients less than 30 years old (yo) with grade 4 gliomas treated with modern surgery and radiotherapy. Overall survival (OS) and progression-free survival (PFS) were characterized using Kaplan-Meier and Cox regression analysis. Results Ninety-seven patients met criteria with median age 23.9 yo at diagnosis. Seventy-seven patients were ≥ 15 yo (79%) and 20 patients were
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-023-04386-4