Body composition modify the association between ambient particulate matter and lung function among asthma patients
The effect of ambient PM 10 and PM 2.5 on lung function modified by body muscle and adipose tissue is not fully understood at present. Our aims were to investigate the association between seasonal average air pollutants and lung function in asthmatic patients modified by body composition indicators....
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Veröffentlicht in: | Environmental science and pollution research international 2023-08, Vol.30 (37), p.88060-88071 |
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Sprache: | eng |
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Zusammenfassung: | The effect of ambient PM
10
and PM
2.5
on lung function modified by body muscle and adipose tissue is not fully understood at present. Our aims were to investigate the association between seasonal average air pollutants and lung function in asthmatic patients modified by body composition indicators. In this cross-sectional study, we recruited 914 doctor-diagnosed asthmatic patients, and performed interaction and stratified analysis using the median values of total body muscle (TBM), total body fat (TBF), and percentage body fat (PBF) as well as body mass index (BMI) =25 as the cutoff points of the high/low body composition groups. The adjusted
R
2
values of the developed LUR models of PM
2.5
and PM
10
were 91.4% and 90.5% and also verified by cross-validation, respectively. After adjusting for confounding factors, we found that TBM significantly modified the association between PM
10
and lung function among asthma patients (interaction
P
value 25 and high TBF, the increase in PM
10
was associated with the decrease in lung function. The asthma patients with obesity and low total body muscle were more susceptible to adverse effects of PM
10
on lung function. |
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ISSN: | 1614-7499 0944-1344 1614-7499 |
DOI: | 10.1007/s11356-023-28597-4 |