Relapsing GABA(A) Receptor Encephalitis After Stem Cell Transplant for Acute Myeloid Leukaemia
Brain MRI revealed multiple cortical and subcortical T2/FLAIR hyperintensities over bilateral frontal and temporal regions without diffusion restriction or contrast enhancement (Fig. 1: Panel 1: MRI brain at the onset of the index event. (a – e): Axial T2/FLAIR images demonstrating multiple cortical...
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| Veröffentlicht in: | Canadian journal of neurological sciences 2024-07, Vol.51 (4), p.581-584 |
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| container_title | Canadian journal of neurological sciences |
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| creator | Ooi, Joshua Chin Ern Pillai, Presaad Lee, Shirley Ong, Sheila Ai Mei Koh, Kee Leong Chia, Yuen Kang |
| description | Brain MRI revealed multiple cortical and subcortical T2/FLAIR hyperintensities over bilateral frontal and temporal regions without diffusion restriction or contrast enhancement (Fig. 1: Panel 1: MRI brain at the onset of the index event. (a – e): Axial T2/FLAIR images demonstrating multiple cortical and subcortical lesions involving the bilateral frontal and temporal lobes. Viral PCR analysis for herpes simplex viruses 1&2, human herpesviruses 6&7, human parvovirus B19, cytomegalovirus, enterovirus, adenovirus, human parechovirus, along with varicella-zoster, mumps, Epstein-Barr, John Cunningham, and Burkitt viruses were negative. A recent case series revealed that patients with anti-GABA(A)R encephalitis may display extensive confluent lesions, deviating from the usual pattern of multiple spotted cortical and subcortical lesions. |
| doi_str_mv | 10.1017/cjn.2023.252 |
| format | Article |
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(a – e): Axial T2/FLAIR images demonstrating multiple cortical and subcortical lesions involving the bilateral frontal and temporal lobes. Viral PCR analysis for herpes simplex viruses 1&2, human herpesviruses 6&7, human parvovirus B19, cytomegalovirus, enterovirus, adenovirus, human parechovirus, along with varicella-zoster, mumps, Epstein-Barr, John Cunningham, and Burkitt viruses were negative. A recent case series revealed that patients with anti-GABA(A)R encephalitis may display extensive confluent lesions, deviating from the usual pattern of multiple spotted cortical and subcortical lesions.</description><identifier>ISSN: 0317-1671</identifier><identifier>EISSN: 2057-0155</identifier><identifier>DOI: 10.1017/cjn.2023.252</identifier><identifier>PMID: 37434473</identifier><language>eng</language><publisher>New York, USA: Cambridge University Press</publisher><subject>Antibodies ; Apheresis ; Aquaporins ; Biopsy ; COVID-19 vaccines ; Disease prevention ; Disease transmission ; Electroencephalography ; Encephalitis ; Hypoxia ; Immunoglobulins ; Immunology ; Immunotherapy ; Letter to the Editor: New Observation ; Leukemia ; Patients ; Pneumonia ; Stem cell transplantation</subject><ispartof>Canadian journal of neurological sciences, 2024-07, Vol.51 (4), p.581-584</ispartof><rights>The Author(s), 2023. 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J. Neurol. Sci</addtitle><description>Brain MRI revealed multiple cortical and subcortical T2/FLAIR hyperintensities over bilateral frontal and temporal regions without diffusion restriction or contrast enhancement (Fig. 1: Panel 1: MRI brain at the onset of the index event. (a – e): Axial T2/FLAIR images demonstrating multiple cortical and subcortical lesions involving the bilateral frontal and temporal lobes. Viral PCR analysis for herpes simplex viruses 1&2, human herpesviruses 6&7, human parvovirus B19, cytomegalovirus, enterovirus, adenovirus, human parechovirus, along with varicella-zoster, mumps, Epstein-Barr, John Cunningham, and Burkitt viruses were negative. A recent case series revealed that patients with anti-GABA(A)R encephalitis may display extensive confluent lesions, deviating from the usual pattern of multiple spotted cortical and subcortical lesions.</description><subject>Antibodies</subject><subject>Apheresis</subject><subject>Aquaporins</subject><subject>Biopsy</subject><subject>COVID-19 vaccines</subject><subject>Disease prevention</subject><subject>Disease transmission</subject><subject>Electroencephalography</subject><subject>Encephalitis</subject><subject>Hypoxia</subject><subject>Immunoglobulins</subject><subject>Immunology</subject><subject>Immunotherapy</subject><subject>Letter to the Editor: New Observation</subject><subject>Leukemia</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Stem cell transplantation</subject><issn>0317-1671</issn><issn>2057-0155</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNptkMlLxDAYR4MoOi43zxLwMoIdszVJj3VwgxHB5WpI26_asZtJe_C_N-qoIOaSHB4vPx5C-5TMKKHqJF-2M0YYn7GYraEJI7GKCI3jdTQhnKqISkW30Lb3S0KYjKXYRFtcCS6E4hP0eAu17X3VPuGL9DSdpkf4FnLoh87hszY8nm1dDZXHaTmAw3cDNHgOdY3vnW19X9t2wGVg03wcAF-_Qd1VBV7A-GKhqewu2iht7WFvde-gh_Oz-_lltLi5uJqniyhnWg8Rk6qELJxSctA2sZLFxCqlclEUYQ4nMmGWCFYKnUlSUikzXVgFieVZwgXfQdMvb--61xH8YJrK52GnbaEbvWGaS5ZooXVAD_-gy250bVhnOOWcUyY_hcdfVO467x2UpndVY92bocR8dDehu_nobkL3gB-spGPWQPEDf4cOwGzls03mquIJfr_91_gO9OiLrg</recordid><startdate>202407</startdate><enddate>202407</enddate><creator>Ooi, Joshua Chin Ern</creator><creator>Pillai, Presaad</creator><creator>Lee, Shirley</creator><creator>Ong, Sheila Ai Mei</creator><creator>Koh, Kee Leong</creator><creator>Chia, Yuen Kang</creator><general>Cambridge University Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6235-3712</orcidid></search><sort><creationdate>202407</creationdate><title>Relapsing GABA(A) Receptor Encephalitis After Stem Cell Transplant for Acute Myeloid Leukaemia</title><author>Ooi, Joshua Chin Ern ; Pillai, Presaad ; Lee, Shirley ; Ong, Sheila Ai Mei ; Koh, Kee Leong ; Chia, Yuen Kang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c288t-267febbbbf63e8a9a6250a777c4ddece30692a042f48b60f166b8da7e9a3b9343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antibodies</topic><topic>Apheresis</topic><topic>Aquaporins</topic><topic>Biopsy</topic><topic>COVID-19 vaccines</topic><topic>Disease prevention</topic><topic>Disease transmission</topic><topic>Electroencephalography</topic><topic>Encephalitis</topic><topic>Hypoxia</topic><topic>Immunoglobulins</topic><topic>Immunology</topic><topic>Immunotherapy</topic><topic>Letter to the Editor: New Observation</topic><topic>Leukemia</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Stem cell transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ooi, Joshua Chin Ern</creatorcontrib><creatorcontrib>Pillai, Presaad</creatorcontrib><creatorcontrib>Lee, Shirley</creatorcontrib><creatorcontrib>Ong, Sheila Ai Mei</creatorcontrib><creatorcontrib>Koh, Kee Leong</creatorcontrib><creatorcontrib>Chia, Yuen Kang</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Canadian journal of neurological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ooi, Joshua Chin Ern</au><au>Pillai, Presaad</au><au>Lee, Shirley</au><au>Ong, Sheila Ai Mei</au><au>Koh, Kee Leong</au><au>Chia, Yuen Kang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relapsing GABA(A) Receptor Encephalitis After Stem Cell Transplant for Acute Myeloid Leukaemia</atitle><jtitle>Canadian journal of neurological sciences</jtitle><addtitle>Can. J. Neurol. Sci</addtitle><date>2024-07</date><risdate>2024</risdate><volume>51</volume><issue>4</issue><spage>581</spage><epage>584</epage><pages>581-584</pages><issn>0317-1671</issn><eissn>2057-0155</eissn><abstract>Brain MRI revealed multiple cortical and subcortical T2/FLAIR hyperintensities over bilateral frontal and temporal regions without diffusion restriction or contrast enhancement (Fig. 1: Panel 1: MRI brain at the onset of the index event. (a – e): Axial T2/FLAIR images demonstrating multiple cortical and subcortical lesions involving the bilateral frontal and temporal lobes. Viral PCR analysis for herpes simplex viruses 1&2, human herpesviruses 6&7, human parvovirus B19, cytomegalovirus, enterovirus, adenovirus, human parechovirus, along with varicella-zoster, mumps, Epstein-Barr, John Cunningham, and Burkitt viruses were negative. 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| subjects | Antibodies Apheresis Aquaporins Biopsy COVID-19 vaccines Disease prevention Disease transmission Electroencephalography Encephalitis Hypoxia Immunoglobulins Immunology Immunotherapy Letter to the Editor: New Observation Leukemia Patients Pneumonia Stem cell transplantation |
| title | Relapsing GABA(A) Receptor Encephalitis After Stem Cell Transplant for Acute Myeloid Leukaemia |
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