A critical appraisal of the ATLAS trial of maintenance therapy for multiple myeloma: end points, censoring and equipoise

A critical appraisal of the ATLAS trial of maintenance therapy for multiple myeloma: end points, censoring and equipoise

A recent report from the ATLAS trial comparing different maintenance strategies following haematopoeitic stem cell transplantation for multiple myeloma provides an opportunity to explore various themes of critical appraisal, including end points, the equipoise of trial design, and the part censoring...

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Veröffentlicht in:Nature reviews. Clinical oncology 2023-11, Vol.20 (11), p.735-736
Hauptverfasser: Mohyuddin, Ghulam Rehman, Meirson, Tomer
Format: Artikel
Sprache:eng
Schlagworte:
631/67/1059/153
692/308/2779/777
692/699/1541/1990/804
692/700/3935
692/700/565/1436/1437
Cancer
Content analysis
Drug withdrawal
Medicine
Medicine & Public Health
Multiple myeloma
News & Views
news-and-views
Oncology
Patients
Stem cell transplantation
Stem cells
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Beschreibung
Zusammenfassung:A recent report from the ATLAS trial comparing different maintenance strategies following haematopoeitic stem cell transplantation for multiple myeloma provides an opportunity to explore various themes of critical appraisal, including end points, the equipoise of trial design, and the part censoring can play in the validity of results.
ISSN:1759-4774
1759-4782
DOI:10.1038/s41571-023-00801-x