Granulomatous myopathy co-existent immune-mediated necrotizing myopathy: A case report

Granulomatous myopathy (GM) is a rare disease characterized by non-caseating inflammation of the skeletal muscle, with sarcoidosis as a common cause. Here, we report a case of GM co-existent immune-mediated necrotizing myopathy (IMNM) in which an anti-signal recognition particle (SRP) antibody was positive and a muscle biopsy showed a non-caseating granulomatous structure, along with myofiber necrosis and inflammatory cell infiltration. •Sarcoidosis is a common cause of Granulomatous myopathy.•The patient has positive anti-SRP antibody.•This is a case of granulomatous myopathy co-existent with immune-mediated necrotizing myopathy.