Antipyretic and antinociceptive effects of methanolic extract of C. iria L. tuber

Cyperus iria L. is a sedge belongs to Cyperaceae family. Tuber of this plant is traditionally used in fever. This study aimed to verify the effectiveness of this plant part against fever. Additionally, antinociceptive effect of the plant was evaluated. Antipyretic effect was evaluated by yeast induced hyperthermia experiment. Antinociceptive effect was determined by acetic acid induced writhing test and hot plate test. Four different doses of plant extract were used in mice model. Extract at dose of 400 mg/kg.bw produced greater effect than paracetamol; reduction of elevated mice body temperature was observed by 2.6 °F and 4.2 °F after 4 h by paracetamol and 400 mg/kg.bw extract respectively. In acetic acid writhing test, extract at 400 mg/kg.bw and diclofenac were found to have equivalent effects producing percentage inhibition of writhing of 67.68% and 68.29% respectively. In hot plat test, significant reduction in latency was also observed after administration of plant extracts. Mean percent maximal effect was 83.55% and 67.26% for ketorolac and extract (400 mg/kg.bw) respectively. Our study endorsed the traditional use of C. iria tuber in fever with possible antinociceptive effects. [Display omitted] •Methanolic extract of C. iria L. tuber showed greater antipyretic effect than paracetamol in mice model.•The extract also produced remarkable antinociceptive effects in peripheral and spinal analgesia.