Immunologic biomarkers for bacterial meningitis

•The inflammatory process is triggered in the response to microbial meningitis.•Changes in concentrations of cytokines and APPs may be potential indicator for laboratory meningitis diagnosis.•Some immunologic biomarkers exhibited ability to discriminate among patients with bacterial and viral meningitis.•It is important in future studies to evaluate a combination of various biomarkers. Meningitis is defined as the inflammation of the meninges that is most often caused by various bacterial and viral pathogens, and is associated with high rates of mortality and morbidity. Early detection of bacterial meningitis is essential to appropriate antibiotic therapy. Alterations in immunologic biomarkers levels have been considered the diagnostic approach in medical laboratories for the identifying of infections. The early increasing immunologic mediators such as cytokines and acute phase proteins (APPs) during bacterial meningitis have made they significant indicators for laboratory diagnosis. Immunology biomarkers showed wide variable sensitivity and specificity values that influenced by different reference values, selected a certain cutoff point, methods of detection, patient characterization and inclusion criteria, as well as etiology of meningitis and time of CSF or blood specimens’ collection. This study provides an overview of different immunologic biomarkers as diagnostic markers for the identification of bacterial meningitis and their efficiencies in the differentiating of bacterial from viral meningitis.