Diagnosing and treating issues in cryo-EM map-derived models

In this issue of Structure, Reggiano et al.1 take the evaluation of cryo-EM models to the next level, combining several metrics into one. The new method, MEDIC, evaluates models at the residue level, helping to guide improvements and interpretation of models derived from cryo-EM maps. In this issue of Structure, Reggiano et al. take the evaluation of cryo-EM models to the next level, combining several metrics into one. The new method, MEDIC, evaluates models at the residue level, helping to guide improvements and interpretation of models derived from cryo-EM maps.