Aberrant spontaneous brain activity in patients with thyroid-associated ophthalmopathy with and without optic neuropathy: a resting-state functional MRI study

Objectives To investigate the brain functional alterations in dysthyroid optic neuropathy (DON) by evaluating spontaneous neural activity, using functional magnetic resonance imaging (fMRI) with regional homogeneity (ReHo), and its relationship with ophthalmologic performance. Methods Forty-seven pa...

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Veröffentlicht in:	European radiology 2023-11, Vol.33 (11), p.7981-7991
Hauptverfasser:	Liu, Ping, Luo, Ban, Feng, Ying, Chen, Lang, Zhao, Ya-li, Wang, Qiu-xia, Liang, Si-pei, Wu, Hong-yu, Yuan, Gang, Jiang, Gui-hua, Zhang, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Brain Brain - diagnostic imaging Brain mapping Brain Mapping - methods Cortex (cingulate) Cortex (temporal) Diagnostic Radiology Diagnostic systems Differential diagnosis Fields (mathematics) Functional magnetic resonance imaging Graves Ophthalmopathy - complications Graves Ophthalmopathy - diagnostic imaging Graves' disease Homogeneity Humans Imaging Internal Medicine Interventional Radiology Magnetic resonance imaging Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Neuro Neuroimaging Neuroradiology Optic Nerve Diseases Optic neuropathy Performance evaluation Precentral gyrus Radiology Superior temporal gyrus Temporal gyrus Thyroid Thyroid gland Ultrasound Variance analysis
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Zusammenfassung:	Objectives To investigate the brain functional alterations in dysthyroid optic neuropathy (DON) by evaluating spontaneous neural activity, using functional magnetic resonance imaging (fMRI) with regional homogeneity (ReHo), and its relationship with ophthalmologic performance. Methods Forty-seven patients with thyroid-associated ophthalmopathy (TAO; 20 with DON, 27 with non-DON) and 33 age-, sex-, and education-matched healthy controls (HCs) underwent fMRI. ReHo values were compared using one-way analysis of variance (ANOVA) with post hoc pairwise comparisons (voxel-level p
ISSN:	1432-1084 0938-7994 1432-1084
DOI:	10.1007/s00330-023-09829-0