Hypoxia-stabilized RIPK1 promotes cell death

Hypoxia-stabilized RIPK1 promotes cell death

The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIP...

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Veröffentlicht in:Nature cell biology 2023-07, Vol.25 (7), p.921-922
Hauptverfasser: Ruan, Wei, Eltzschig, Holger K., Yuan, Xiaoyi
Format: Artikel
Sprache:eng
Schlagworte:
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631/80/86/2366
Apoptosis
Biology
Biomedical and Life Sciences
Cancer Research
Cell Biology
Cell death
Chemokines
Crystal structure
Cytokines
Developmental Biology
Hydroxylation
Hypoxia
Inflammation
Inflammatory diseases
Ischemia
Kinases
Life Sciences
Liver
News & Views
news-and-views
Research funding
Stem Cells
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Zusammenfassung:The PHD–pVHL pathway is essential for oxygen-dependent prolyl hydroxylation of HIFA. A recent study identifies RIPK1 as a hydroxylation target in this pathway during hypoxia-induced cell death and presents a 2.8 Å resolution crystal structure of the pVHL–elongin B/C complex bound to hydroxylated RIPK1.
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-023-01176-y