Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment
Conventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-toler...
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| Veröffentlicht in: | Applied biochemistry and biotechnology 2024-03, Vol.196 (3), p.1685-1711 |
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| container_title | Applied biochemistry and biotechnology |
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| creator | Tabasi, Hamed Mollazadeh, Samaneh Fazeli, Elham Abnus, Khalil Taghdisi, Seyed Mohammad Ramezani, Mohammad Alibolandi, Mona |
| description | Conventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-tolerable platform. Herein, we introduce different RNA-based platforms with a special focus on siRNA, miRNA, and mRNA applications in cancer treatment in order to better understand the details of their therapeutic effects. Of note, the co-delivery of RNAs with other distinct RNA or drugs has provided safe, efficient, and novel treatment modalities for cancer treatment.
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| doi_str_mv | 10.1007/s12010-023-04597-5 |
| format | Article |
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| subjects | Antigens Apoptosis Biochemistry Biotechnology Cancer Cancer therapies Cell cycle Chemistry Chemistry and Materials Science Chemotherapy Drug resistance Genes Immunotherapy Infections MicroRNAs MicroRNAs - genetics MicroRNAs - therapeutic use miRNA mRNA Nanoparticles Neoplasms - drug therapy Neoplasms - genetics Nerves Oligonucleotides Oligonucleotides - genetics Oligonucleotides - therapeutic use Review Article Ribonucleic acid RNA RNA polymerase RNA, Double-Stranded RNA, Small Interfering - genetics RNA, Small Interfering - therapeutic use Side effects siRNA Tumors Viral infections |
| title | Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment |
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