Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment

Conventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-toler...

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Veröffentlicht in:Applied biochemistry and biotechnology 2024-03, Vol.196 (3), p.1685-1711
Hauptverfasser: Tabasi, Hamed, Mollazadeh, Samaneh, Fazeli, Elham, Abnus, Khalil, Taghdisi, Seyed Mohammad, Ramezani, Mohammad, Alibolandi, Mona
Format: Artikel
Sprache:eng
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Zusammenfassung:Conventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-tolerable platform. Herein, we introduce different RNA-based platforms with a special focus on siRNA, miRNA, and mRNA applications in cancer treatment in order to better understand the details of their therapeutic effects. Of note, the co-delivery of RNAs with other distinct RNA or drugs has provided safe, efficient, and novel treatment modalities for cancer treatment. Graphical Abstract
ISSN:0273-2289
1559-0291
DOI:10.1007/s12010-023-04597-5