A novel metabolic reprogramming strategy for the treatment of targeting to heart injury-mediated macrophages

•ZIF-8zyme shows sustained and accelerated anti-inflammation effects.•ZIF-8zyme exhibits anti-inflammation properties against M1 macrophages.•ZIF-8zyme develops into a permissive microenvironment characterized by proregenerative immune cell phenotypes and a substantially improved AMI recovery. M1 ma...

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Veröffentlicht in:International immunopharmacology 2023-09, Vol.122, p.110377-110377, Article 110377
Hauptverfasser: Chen, ShuRui, Luo, Xiang, Sun, Yu, Jin, Wen, He, Rongrong
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Sprache:eng
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Zusammenfassung:•ZIF-8zyme shows sustained and accelerated anti-inflammation effects.•ZIF-8zyme exhibits anti-inflammation properties against M1 macrophages.•ZIF-8zyme develops into a permissive microenvironment characterized by proregenerative immune cell phenotypes and a substantially improved AMI recovery. M1 macrophages polarization has been reported as the direct risk of acute myocardial infarction (AMI) occurrence and worsen AMI prognosis, especially for hyperinflammation-associated AMI. However, clinic treatments remain challenges, including off-target and side-effects. The development of enzyme mimetics could provide effective treatments for a wide variety of diseases. Herein, nanomaterials were used to create artificial hybrid nanozymes. In this study, we synthesized in situ zeolitic imidazolate framework nanozyme (ZIF-8zyme) with anti-oxidative and anti-inflammatory ability to repair microenvironment via reprogramming M1 macrophages polarization. In vitro study reported that a metabolic reprogramming strategy that the improvement of glucose import and glycolysis with ZIF-8zyme via inhibiting ROS levels led to a metabolic crisis within the macrophages. ZIF-8zyme shifted the polarization of M1 macrophages toward higher production of M2 phenotype, decreased proinflammatory cytokines secretion, and promoted significant survival of cardiomyocytes under hyperinflammation condition. Moreover, ZIF-8zyme elicits more potent macrophages-polarizing effects under hyperinflammation condition. Therefore, metabolic reprogramming strategy based on ZIF-8zyme is a promising AMI therapy, especially for hyperinflammation-associated AMI.
ISSN:1567-5769
1878-1705
DOI:10.1016/j.intimp.2023.110377