Risk factors in children with optic nerve hypoplasia and septo‐optic dysplasia

Aim To identify the risk factors for optic nerve hypoplasia (ONH) and septo‐optic dysplasia (SOD). Method A retrospective, population‐based study with case–control design was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada. Cases...

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Veröffentlicht in:Developmental medicine and child neurology 2024-01, Vol.66 (1), p.106-116
Hauptverfasser: Salman, Michael S., Ruth, Chelsea A., Yogendran, Marina S., Rozovsky, Katya, Lix, Lisa M.
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Sprache:eng
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Zusammenfassung:Aim To identify the risk factors for optic nerve hypoplasia (ONH) and septo‐optic dysplasia (SOD). Method A retrospective, population‐based study with case–control design was undertaken using the Population Research Data Repository at the Manitoba Center for Health Policy in Manitoba, Canada. Cases were 111 patients (63 males, 48 females; age range 1–35 years [mean 11 years 6 months, SD 7 years 2 months]) with ONH and SOD diagnosed from 1990 to 2019, matched to 555 unrelated population‐based controls (315 males, 240 females; age range 1–35 years [mean 11 years 6 months, SD 7 years 2 months]) on year of birth, sex, and area of residence. Additionally, 75 cases (46 males, 29 females; age range 2–35 years [mean 12 years 6 months, SD 7 years 2 months]) with ONH and SOD were matched one‐on‐one with sibling controls (40 males, 35 females; age range 0–33 years [mean 11 years 7 months, SD 7 years 10 months], the rest did not have siblings). Several antenatal maternal risk factors associated with ONH and SOD were tested for their association with case and control group membership using adjusted odds ratios (ORs) and 95% confidence intervals (CIs) from a multivariate conditional logistic regression model. The outcome was the risk of developing ONH and SOD. Results Maternal age at conception (OR = 0.91, 95% CI = 0.86–0.96), primigravida (OR = 3.39, 95% CI = 1.92–6.01), and smoking (OR = 2.86, 95% CI = 1.61–5.05) were independently associated with ONH and SOD in the cohort matched to unrelated controls (p 
ISSN:0012-1622
1469-8749
1469-8749
DOI:10.1111/dmcn.15678